Submental fat reduction using sequential treatment approach with cryolipolysis and ATX‐101

Autor:	H Ray, Jalian, Rebecca, Fitzgerald, Beta, Bowen, Sylvia, Gamio
Rok vydání:	2022
Předmět:	Adult Male Chin Injections Subcutaneous Subcutaneous Fat Dermatology Middle Aged Young Adult Treatment Outcome Patient Satisfaction Humans Female Prospective Studies Aged Deoxycholic Acid
Zdroj:	Journal of Cosmetic Dermatology. 21:2437-2444
ISSN:	1473-2165 1473-2130
DOI:	10.1111/jocd.14909
Popis:	Submental fat (SMF) detracts from facial aesthetics and negatively impacts self-image.To evaluate safety, effectiveness, and satisfaction of cryolipolysis and ATX-101 used sequentially to reduce SMF.A prospective, open-label, interventional, single-site study enrolling 22- to 65-year-old participants rated as Grade 4 (extreme) on the Clinician-Rated SMF Rating Scale (CR-SMFRS). Co-primary effectiveness endpoints were proportions of participants with ≥1-grade and ≥2-grade improvement on CR-SMFRS at 12 weeks post final treatment. Additional assessments included ultrasound measurement of fat thickness and Subject Self-Rating Scale (SSRS) scores at 12 weeks post final treatment. Safety was assessed throughout the study.Of 16 enrolled participants, 62.5% were female, mean age of 43, and mean body mass index of 31.8 kg/mSequential treatment with cryolipolysis and ATX-101 was found safe and effective for reducing extreme SMF, resulting in approximately a 2-grade improvement.
Databáze:	OpenAIRE
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