Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy
| Autor: | Natalie J. Galant, Jeffrey N. Higaki, Avijit Chakrabartty, Per Westermark |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Amyloid Neuropathies
Familial medicine.medical_specialty Pathology biology Heart disease business.industry Amyloidosis Cardiomyopathy General Medicine 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences Transthyretin 0302 clinical medicine Cardiac amyloidosis Heart failure medicine biology.protein Humans Cardiomyopathies business Intensive care medicine Polyneuropathy 030217 neurology & neurosurgery Attr amyloidosis |
| Zdroj: | Clinical Science. 131:395-409 |
| ISSN: | 1470-8736 0143-5221 |
| Popis: | Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is an underdiagnosed and important type of cardiomyopathy and/or polyneuropathy that requires increased awareness within the medical community. Raising awareness among clinicians about this type of neuropathy and lethal form of heart disease is critical for improving earlier diagnosis and the identification of patients for treatment. The following review summarizes current criteria used to diagnose both hereditary and wild-type ATTR (ATTRwt) amyloidosis, tools available to clinicians to improve diagnostic accuracy, available and newly developing therapeutics, as well as a brief biochemical and biophysical background of TTR amyloidogenesis. |
| Databáze: | OpenAIRE |
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