An evaluation of dirlotapide to reduce body weight of client-owned dogs in two placebo-controlled clinical studies in Europe
Autor: | J. Gossellin, Jo McKelvie, J. S. Eagleson, S. J. Sunderland, T.G Rowan, J. Sherington, J. A. Wren |
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Rok vydání: | 2007 |
Předmět: |
Male
medicine.medical_specialty Indoles Initial dose Administration Oral Overweight Body weight Placebo Dogs Weight loss Weight Loss medicine Animals Clinical efficacy Dog Diseases Pharmacology General Veterinary Dirlotapide business.industry Body Weight Ownership Surgery Pedigree Europe Treatment Outcome Anesthesia Female Anti-Obesity Agents Carbamates medicine.symptom business Body condition medicine.drug |
Zdroj: | Journal of veterinary pharmacology and therapeutics. 30 |
ISSN: | 0140-7783 |
Popis: | The clinical efficacy for weight loss and safety of dirlotapide in dogs were evaluated in two multi-centre studies with parallel designs. Overweight, adult dogs (n = 245) of various breeds were randomized to treatment with dirlotapide or placebo in a 2:1 ratio. Dirlotapide was administered orally once daily to dogs at an initial dose of 0.05 mg/kg/day commencing on day 0 and doubled after 14 days. Every 28 days, dogs were examined, weighed, body condition scores (BCS) were recorded, and dose was adjusted to meet weight loss targets. Each study comprised three consecutive phases: weight-loss (up to day 196); weight-stabilization (84 days); and post-treatment (28 days). pre-treatment feeding and exercise regimens were continued during treatment. Dirlotapide-treated dogs showed mean weight loss of 15.9% (study A) and 14.0% (study B) by the end of weight loss phase (up to day 196). Percentage weekly weight losses for dirlotapide were significantly greater than for placebo (P < or = 0.0002). Emesis and diarrhoea were experienced in both treatments but were more frequent with dirlotapide; resolution was spontaneous. BCS improved for 75.7-82.5% of dogs on dirlotapide treatment compared with 15.4-41.4% for placebo. Mean dirlotapide dosage at end of weight-loss phase was 0.38 (study A) and 0.29 (study B) mg/kg initial body weight/day. Dirlotapide was found to be clinically safe and effective in the reduction of body weight in overweight dogs. |
Databáze: | OpenAIRE |
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