eNose-TB: A trial study protocol of electronic nose for tuberculosis screening in Indonesia
Autor: | Kuwat Triyana, Shidiq Nur Hidayat, Trisna Julian, Antonia Morita Iswari Saktiawati, Bintari Dwihardiani, Yodi Mahendradhata, Ari Probandari, Siska Dian Wahyuningtias, Riris Andono Ahmad |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Bacterial Diseases Physiology Disease Geographical Locations Machine Learning 0302 clinical medicine Medical Conditions Open Science Medicine and Health Sciences Coughing Mass Screening 030212 general & internal medicine Electronic Nose Virus Testing education.field_of_study Multidisciplinary Transmission (medicine) Trial study Radiology and Imaging Software Engineering Infectious Diseases Breath Tests Medicine Tuberculosis Diagnosis and Management Engineering and Technology Medical emergency Open Source Software Computer and Information Sciences Tuberculosis Asia Science Policy Science Point-of-Care Systems Population Oceania Tuberculosis screening Computer Software 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Artificial Intelligence Registered Report Protocol Support Vector Machines medicine Humans General hospital education Tuberculosis Pulmonary Protocol (science) business.industry Biology and Life Sciences Mycobacterium tuberculosis medicine.disease Tropical Diseases 030104 developmental biology ROC Curve Indonesia Case-Control Studies People and Places Clinical Medicine business Physiological Processes |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 4, p e0249689 (2021) |
ISSN: | 1932-6203 0456-7498 |
Popis: | Background Even though conceptually, Tuberculosis (TB) is almost always curable, it is currently the world’s leading infectious killer. Patients with pulmonary TB are the source of transmission. Approximately 23% of the world’s population is believed to be latently infected with TB bacteria, and 5–15% of them will progress at any point in time to develop the disease. There was a global diagnostic gap of 2.9 million between notifications of new cases and the estimated number of incident cases, and Indonesia carries the third-highest of this gap. Therefore, screening TB among the community is of great importance to prevent further transmission and infection. The electronic nose for screening TB (eNose-TB) project is initiated in Yogyakarta, Indonesia, to screen TB by breath test with an electronic-nose that is easy-to-use, point-of-care, does not expose patients to radiation, and can be produced at low cost. Methods/Design The objectives of the two-phase planned project are to: 1) investigate the potential of an eNose-TB as a screening tool in Indonesia, in comparison with screening with clinical symptoms and chest radiology, which are currently used as a standard, and 2) analyze the time and cost of a screening algorithm with eNose-TB to obtain additional case detection. A cross-sectional study will be conducted in the first phase to validate the eNose-TB. The validation phase will involve 395 presumptive TB patients in the Surakarta General Hospital, Central Java. In the second phase, a cross-sectional research will be conducted, involving 1,383 adults and children in the municipality of Yogyakarta and Kulon Progo district of Yogyakarta Province. Discussion The findings will provide data concerning the sensitivity and specificity of the eNose-TB as a screening tool for tuberculosis, and the time and cost analysis of a screening algorithm with the eNose. Trial registration NCT04567498; https://clinicaltrials.gov/. |
Databáze: | OpenAIRE |
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