Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development
| Autor: | Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
tip cell specification
Angiogenesis JUNB Morphogenesis Neovascularization Physiologic Review AP-1 transcription factors neurovascular interactions Biology Catalysis vascular development lcsh:Chemistry Inorganic Chemistry angiogenesis Cell Movement medicine Animals Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Transcription factor Spectroscopy Organic Chemistry Endothelial Cells General Medicine Embryonic stem cell Computer Science Applications Cell biology Endothelial stem cell Transcription Factor AP-1 AP-1 transcription factor medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Angiogenesis Inducing Agents JunB Blood vessel Transcription Factors |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 2804, p 2804 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Blood vessels are essential for the formation and maintenance of almost all functional tissues. They play fundamental roles in the supply of oxygen and nutrition, as well as development and morphogenesis. Vascular endothelial cells are the main factor in blood vessel formation. Recently, research findings showed heterogeneity in vascular endothelial cells in different tissue/organs. Endothelial cells alter their gene expressions depending on their cell fate or angiogenic states of vascular development in normal and pathological processes. Studies on gene regulation in endothelial cells demonstrated that the activator protein 1 (AP-1) transcription factors are implicated in angiogenesis and vascular development. In particular, it has been revealed that JunB (a member of the AP-1 transcription factor family) is transiently induced in endothelial cells at the angiogenic frontier and controls them on tip cells specification during vascular development. Moreover, JunB plays a role in tissue-specific vascular maturation processes during neurovascular interaction in mouse embryonic skin and retina vasculatures. Thus, JunB appears to be a new angiogenic factor that induces endothelial cell migration and sprouting particularly in neurovascular interaction during vascular development. In this review, we discuss the recently identified role of JunB in endothelial cells and blood vessel formation. |
| Databáze: | OpenAIRE |
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