Psychopharmacological Profile of the Alkaloid Psychollatine as a 5HT2A/C Serotonin Modulator
| Autor: | Elaine Elisabetsky, Fernanda Lima Both, Vitor Alberto Kerber, Lisiane Meneghini, A. T. Henriques |
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| Rok vydání: | 2005 |
| Předmět: |
Psychopharmacology
medicine.drug_class Pharmaceutical Science Ritanserin Pharmacology Models Biological Imipramine Anxiolytic Indole Alkaloids Analytical Chemistry chemistry.chemical_compound Memory Drug Discovery medicine Glycosides Diazepam Plants Medicinal Molecular Structure GABAA receptor Organic Chemistry GABA receptor antagonist Receptors GABA-A Serotonin Receptor Agonists Anti-Anxiety Agents nervous system Complementary and alternative medicine chemistry Receptors Serotonin Monoterpenes Molecular Medicine Serotonin Psychotria Brazil medicine.drug Picrotoxin |
| Zdroj: | Journal of Natural Products. 68:374-380 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np049695y |
| Popis: | Behavioral effects of psychollatine, a new glycoside indole monoterpene alkaloid isolated from Psychotria umbellata, was investigated in models of anxiety, depression, memory, tremor, and sedation related to 5-HT and/or GABA neurotransmission. The GABA antagonist picrotoxin and the 5-HT2 antagonist ritanserin were used to examine the role of GABA and 5-HT2 receptors in psychollatine-induced effects. In the light/dark and hole-board models of anxiety, diazepam (0.75 mg/kg) and psychollatine (7.5 and 15 mg/kg) showed anxiolytic-like effect at doses that do not increase sleeping time nor alter spontaneous locomotor activity. The anxiolytic effect of psychollatine was prevented by prior administration of ritanserin, but not of picrotoxin, indicating that 5-HT2 but not GABA receptors are implicated. In the forced swimming model of depression, psychollatine (3 and 7.5 mg/kg) effects were comparable to the antidepressants imipramine (15 mg/kg) and fluoxetine (20 mg/kg). Psychollatine suppressed oxotremorine-induced tremors in all doses. In the step-down learning paradigm, diazepam (0.85 mg/kg), MK-801 (0.15 mg/kg), and psychollatine 100 mg/kg impaired the acquisition of learning and memory consolidation, without interfering with retrieval. It is concluded that the effects of psychollatine at the central nervous system involve serotonergic 5HT2(A/C) receptors. |
| Databáze: | OpenAIRE |
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