Tumor-induced osteomalacia - Current imaging modalities and a systematic approach for tumor localization
| Autor: | Shifali Dumeer, Fabrizio Remotti, Arun Reddy, Ijeuru Chikeka, Randy Yeh, Tony T Wong, Bhagwant Rai Mittal, Sampanna Jung Rayamajhi |
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| Rok vydání: | 2019 |
| Předmět: |
Fibroblast growth factor 23
Diagnostic Imaging medicine.medical_specialty Paraneoplastic Syndromes 030218 nuclear medicine & medical imaging Imaging modalities 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Bone pain Osteomalacia Neoplasms Connective Tissue medicine.diagnostic_test business.industry Muscle weakness Magnetic resonance imaging medicine.disease Phosphaturic mesenchymal tumor Fibroblast Growth Factor-23 030220 oncology & carcinogenesis Plain radiographs Radiology medicine.symptom business |
| Zdroj: | Clinical imaging. 56 |
| ISSN: | 1873-4499 |
| Popis: | Paraneoplastic syndromes are symptom complexes that cannot be readily explained by local or distant spread of the tumor. They can occur due to hormone production, autoimmunity or other biologically active products produced by the tumor, etc. Tumor induced osteomalacia is a rare paraneoplastic syndrome in which the manifestation is mainly musculoskeletal such as bone pain, fractures and muscle weakness as a consequence of elaboration of fibroblast growth factor 23 (FGF23) by the tumor. Most of these tumors are solitary and small and hence localization of these tumors is often challenging. This review summarizes the various anatomic imaging modalities such as plain radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) and nuclear medicine imaging techniques in the evaluation of these tumors. |
| Databáze: | OpenAIRE |
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