Disease spectrum of patients with antineutrophil cytoplasmic autoantibodies of defined specificity: distinct differences between patients with anti‐proteinase 3 and anti‐myeloperoxidase autoantibodies
| Autor: | C Hageluken, Cornelis Kallenberg, Reinold O. B. Gans, StevenJ. Hoorntje, Casper F. M. Franssen |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Vasculitis Pathology medicine.medical_specialty Myeloblastin Autoantigens Gastroenterology Antibodies Antineutrophil Cytoplasmic Diagnosis Differential Antibody Specificity Proteinase 3 Internal medicine Immunopathology Internal Medicine medicine Humans cardiovascular diseases Aged Netherlands Peroxidase Retrospective Studies Anti-neutrophil cytoplasmic antibody business.industry Serine Endopeptidases Autoantibody Middle Aged medicine.disease Giant cell arteritis Female Microscopic polyangiitis business Systemic vasculitis |
| Zdroj: | Journal of Internal Medicine. 244:209-216 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1046/j.1365-2796.1998.00357.x |
| Popis: | Objective, To compare the disease spectrum of consecutive patients with antineutrophil cytoplasmic autoantibodies directed against proteinase 3 (anti-PR3) or myeloperoxidase (anti-MPO). Design. Retrospective analysis, Setting. Three teaching hospitals in the Netherlands. Main outcome measures, Clinical features at presentation, histopathological characteristics and outcome. Subjects. All consecutive patients who tested positive for anti-PR3 (n = 46) or anti-MPO (n = 46) over an X-year-period. Results, At diagnosis, patients with anti-PR3 had a higher vasculitis activity index than patients with anti-MPO (P |
| Databáze: | OpenAIRE |
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