Regulation of ion channel structure and function by reactive oxygen-nitrogen species
| Autor: | Junhui Sun, Douglas C. Eaton, Lucky Jain, Karin M. Hardiman, Jonathan S. Stamler, Michael I. Kotlikoff, Gerhard Meissner, Sadis Matalon, Jerry P. Eu |
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| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transmembrane channels Voltage-gated ion channel Physiology Chemistry Inward-rectifier potassium ion channel Respiratory Mucosa Cell Biology N-type calcium channel Reactive Nitrogen Species Ion Channels TRPC1 Biochemistry Physiology (medical) Chloride channel Biophysics Animals Humans Ligand-gated ion channel Muscle Skeletal Reactive Oxygen Species Ion channel |
| Zdroj: | American Journal of Physiology-Lung Cellular and Molecular Physiology. 285:L1184-L1189 |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.00281.2003 |
| Popis: | Ion channels subserve diverse cellular functions. Reactive oxygen and nitrogen species modulate ion channel function by a number of mechanisms including 1) transcriptional regulation of gene expression, 2) posttranslational modifications of channel proteins, i.e. nitrosylation, nitration, and oxidation of key amino acid residues, 3) by altering the gain in other signaling pathways that may in turn lead to changes in channel activity or channel gene expression, and 4) by modulating trafficking or turnover of channel proteins, as typified by oxygen radical activation of NF-kB, with subsequent changes in proteasomal degradation of channel degradation. Regardless of the mechanism, as was discussed in a symposium at the 2003 Experimental Biology Meeting in San Diego, CA, changes in the cellular level of reactive oxygen and nitrogen species can have profound effects on the activity of ion channels and cellular function. |
| Databáze: | OpenAIRE |
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