Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results
| Autor: | Fàtima Sabench, E Raga, Daniel Del Castillo, A Cabrera, Marta París, A. Sánchez, Margarita Vives, Alicia Molina |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Sleeve gastrectomy medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment media_common.quotation_subject 030209 endocrinology & metabolism Cafeteria Diet High-Fat Gastroenterology Glucagon Rats Sprague-Dawley 03 medical and health sciences Random Allocation 0302 clinical medicine Weight loss Gastrectomy Internal medicine Weight Loss Medicine Animals Obesity media_common Nutrition and Dietetics biology business.industry Stomach Appetite biology.organism_classification medicine.disease Ghrelin Rats Disease Models Animal 030211 gastroenterology & hepatology Surgery Laparoscopy medicine.symptom business Energy Intake Hormone |
| Zdroj: | Obesity surgery. 28(10) |
| ISSN: | 1708-0428 |
| Popis: | AIM Laparoscopic gastric plication (LGP) is a bariatric surgical technique based on the anatomical principles of laparoscopic sleeve gastrectomy (LSG), but its effects on the metabolic profile are still uncertain. The aim of our study is to compare the changes in weight, metabolic parameters and gastric histology following intervention by gastric plication (GP) and sleeve gastrectomy (SG) in an experimental model of obesity. METHODS To conduct the study, 32 8-week-old male Sprague-Dawley rats (Charles River®) were fattened by means of a cafeteria diet and randomly assigned to the following experimental groups: group 1: GP (n = 12); group 2: SG (n = 12) and group 3: sham (n = 8). RESULTS Unlike the SG group, the GP group attained the weight of the sham group at the end of the experiment (week 16). The GP group continued to eat more cafeteria diet than the SG group. In addition, the SG group achieved better glycaemic control than the GP group. Significantly higher plasma ghrelin levels were observed at week 16 in the GP group than in the SG group (2.29 ± 0.5 vs 1.07 ± 0.4, p |
| Databáze: | OpenAIRE |
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