Evaluation of the Effects of Atorvastatin and Ischemic Postconditioning Preventing on the Ischemia and Reperfusion Injury: Experimental Study in Rats
| Autor: | João Victor Cunha Miranda, José Carlos Dorsa Vieira Pontes, Murilo Henrique Martins de Almeida, Giovanna Serra da Cruz Vendas, Carlos Henrique Marques dos Santos, Euler de Azevedo Neto, Ian de Oliveira Chaves, Trícia Luna Sampaio, Letícia do Espírito Santos Dias, João Victor Durães Gomes Oliva, Henrique Budib Dorsa Pontes, Doroty Mesquita Dourado |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Statin medicine.drug_class Atorvastatin lcsh:Surgery Ischemia Urology Ileum 030204 cardiovascular system & hematology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Reperfusion Injury/Prevention & Control medicine Animals Rats Wistar Ischemic Preconditioning Ischemic Postconditioning Lung business.industry Hydroxymethylglutaryl-CoA lcsh:RD1-811 General Medicine medicine.disease Rats Disease Models Animal Oxidative Stress medicine.anatomical_structure lcsh:RC666-701 030220 oncology & carcinogenesis Reperfusion Injury Ischemic preconditioning Surgery Original Article Cardiology and Cardiovascular Medicine business Reperfusion injury Oxidative stress medicine.drug |
| Zdroj: | Brazilian Journal of Cardiovascular Surgery, Volume: 33, Issue: 1, Pages: 72-81, Published: FEB 2018 Brazilian Journal of Cardiovascular Surgery Brazilian Journal of Cardiovascular Surgery, Vol 33, Iss 1, Pp 72-81 Brazilian Journal of Cardiovascular Surgery v.33 n.1 2018 Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) instacron:SBCCV |
| Popis: | Introduction: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning. Methods: 41 Wistar rats (Rattus norvegicus albinus) were distributed in 5 groups: Ischemia and Reperfusion (A), Ischemic Postconditioning (B), Statin (C), Ischemic Postconditioning + Statins (D) and SHAM (E). After euthanasia, lungs, liver, kidneys and ileum were resected and submitted to histopathological analysis. Results: The average of lung parenchymal injury was A=3.6, B=1.6, C=1.2, D=1.2, E=1 (P=0.0029). The average of liver parenchymal injury was A=3, B=1.5, C=1.2, D=1.2, E = 0 (P |
| Databáze: | OpenAIRE |
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