Human Papillomavirus (HPV) DNA Detection Using Self-Sampling Devices in Women Undergoing Long Term Immunosuppressive Therapy

Autor: Gajane Martirosian, Barbara Suchońska, Mariusz Sikora, Zoulikha Jabiry-Zieniewicz, Lidia Rudnicka, Aleksandra Wielgos, Jolanta Gozdowska, Urszula Ołdakowska-Jedynak, Bronisława Pietrzak, Miroslaw Wielgos, Magdalena Durlik
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
cervical cancer
medicine.medical_treatment
lcsh:QR1-502
Cervix Uteri
030230 surgery
Alphapapillomavirus
lcsh:Microbiology
renal transplant recipients
Human Papillomavirus DNA Tests
0302 clinical medicine
Genotype
030212 general & internal medicine
Prospective Studies
human papillomavirus
Cervical cancer
Cervical screening
immunosuppression
Immunosuppression
Middle Aged
Vaccination
Infectious Diseases
medicine.anatomical_structure
Female
Adult
medicine.medical_specialty
HPV
Adolescent
immunosuppressive therapy
Article
03 medical and health sciences
Young Adult
Virology
Internal medicine
medicine
liver transplant recipients
Humans
Cervix
Genotyping
Aged
Immunosuppression Therapy
business.industry
Papillomavirus Infections
medicine.disease
vaccination
Transplantation
DNA
Viral
business
transplantation
Zdroj: Viruses
Viruses, Vol 12, Iss 962, p 962 (2020)
Volume 12
Issue 9
ISSN: 1999-4915
Popis: Immunosuppression is a risk factor of persistent human papillomavirus (HPV) infections, which might lead to development of (pre)malignant lesions of the cervix and lower anogenital tract. Results of HPV DNA testing using cervicovaginal self-samples are comparable to those that are clinician-obtained and therefore might be used in cervical screening. The aim of this study was to assess the prevalence of high-risk HPV (hrHPV) infections, their risk factors and the genotypes distribution among women undergoing immunosuppressive therapy. Women undergoing immunosuppressive therapy for at least three months due to solid organ transplantation or autoimmune disorders were asked to self-collect samples for HPV testing using cervicovaginal brushes and complete questionnaires regarding cervical cancer risk factors. HPV DNA detection and genotyping were performed using Genotyping kit HPV GP version 2. hrHPV was detected in 26/90 (28.9%) specimens. Genotyping revealed a broad range of hrHPV, with type 16 being the most common genotype (11/26). The components of bivalent/quadrivalent or nonavalent vaccines cover all genotypes present in 4.4% and 17.8% women, respectively, and occur as a co-infection with other types in 12.2% and 23.3% of women, respectively. The only feature significantly associated with being hrHPV-positive was having at least two lifetime sexual partners. The high prevalence of hrHPV infections among immunosuppressed women emphasizes the need for regular cervical cancer screening with HPV DNA testing, which might be performed on self-collected specimen.
Databáze: OpenAIRE
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