Altered Hypothalamic-Pituitary-Adrenal Axis Activity in Patients with Chronic Heart Failure
| Autor: | A. S. Poskrebysheva, Iu. V. Smurova, Valery Grinevich, Gustav F. Jirikowski, Iu. E. Morozov, Elena V. Sivukhina, A. A. Dolzhikov |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system Vasopressin medicine.medical_specialty Hydrocortisone Corticotropin-Releasing Hormone Vasopressins Endocrinology Diabetes and Metabolism Clinical Biochemistry Pituitary-Adrenal System Biochemistry Endocrinology Adrenocorticotropic Hormone Zona fasciculata Anterior pituitary Internal medicine medicine Humans Aged Aged 80 and over Heart Failure Adrenal cortex business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Hypothalamus Heart failure Female business hormones hormone substitutes and hormone antagonists Hypothalamic–pituitary–adrenal axis Glucocorticoid medicine.drug |
| Zdroj: | Hormone and metabolic research |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | Neuroendocrine factors play an important role in the pathogenesis of chronic heart failure. Despite numerous clinical and experimental studies, the role of the hypothalamic-pituitary-adrenal axis and glucocorticoid hormones is not fully characterised. Here we present a study of plasma cortisol concentration in 74 chronic heart failure patients, divided into four groups based on NYHA functional classes I-IV, and in 17 control subjects. In parallel, we performed morphological analysis of the hypothalamic-pituitary-adrenal axis components from 8 male patients who had died from chronic heart failure, and 9 male controls. In our study we applied immunohistochemical method and quantitative analysis to investigate an expression of hypothalamic neurohormones (corticotropin-releasing hormone, vasopressin) and adrenocorticotropin hormone in the pituitary, as well as performed general histological examination of the adrenal cortex. Measurement of morning cortisol concentration in plasma of chronic heart failure patients revealed neither difference compared to controls nor with the severity of the disease. Despite this, a two-fold increase in the density of corticotropin-releasing hormone-immunoreactive neurons as well as a two-fold increase in the number of corticotropin-releasing hormone neurons co-expressing vasopressin in the hypothalamic paraventricular nucleus were found. In the anterior pituitary the density of adrenocorticotropin hormone-immunoreactive cells was significantly increased. General histological analysis of the adrenal cortex revealed a drastic thinning of the zona fasciculata and dystrophic changes in corticocytes. Structural changes, observed in the adrenal cortex, suggest a relative glucocorticoid deficiency, which may contribute to corticotropin-releasing hormone and adrenocorticotropin hormone upregulation in hypothalamus and pituitary of chronic heart failure patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|