Can the positive association of osteocalcin with testosterone be unmasked when the preeminent hypothalamic–pituitary regulation of testosterone production is impaired? The model of spinal cord injury
| Autor: | J Samavat, Michaela Luconi, Arcangelo Barbonetti, Felice Francavilla, Alessio Martorella, Settimio D'Andrea, Sandro Francavilla, Giorgio Felzani |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Bone metabolism Pituitary Diseases Endocrinology Diabetes and Metabolism Osteocalcin Population 030209 endocrinology & metabolism Bone remodeling 03 medical and health sciences 0302 clinical medicine Endocrinology Hypergonadotropic hypogonadism Internal medicine Androgen deficiency Hypogonadism Insulin Vitamin D Vitamin D and neurology Humans Medicine Testosterone education Spinal cord injury Spinal Cord Injuries Aged education.field_of_study biology business.industry Middle Aged medicine.disease Diabetes and Metabolism 030220 oncology & carcinogenesis biology.protein business |
| Zdroj: | Journal of Endocrinological Investigation. 42:167-173 |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-018-0897-x |
| Popis: | Osteocalcin (OCN), released from the bone matrix during the resorption phase, in its undercarboxylated form, stimulates testosterone (T) biosynthesis in mouse and a loss-of-function mutation of its receptor was associated with hypergonadotropic hypogonadism in humans. Nevertheless, when population-based studies have explored the OCN-T association, conflicting results have been reported. Hypothesizing that the evidence of a positive association between OCN and T could have been hindered by the preeminent role of a well-functioning hypothalamus–pituitary axis in promoting T biosynthesis, we explored this association in men with chronic spinal cord injury (SCI), exhibiting high prevalence of non-hypergonadotropic androgen deficiency. Fifty-five consecutive men with chronic SCI underwent clinical/biochemical evaluations, including measurements of total T (TT), OCN and 25(OH)D levels. Free T (FT) levels were calculated by the Vermeulen formula. Comorbidity was scored by Charlson comorbidity index (CCI). A biochemical androgen deficiency (TT |
| Databáze: | OpenAIRE |
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