Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research
| Autor: | Jessica Görne, Svetlana Surkova, Sergey V. Nuzhdin, Maria Samsonova |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Sex Differentiation animal structures genetic structures Doublesex Embryonic Development Biology Eye Article 03 medical and health sciences Sex Factors 0302 clinical medicine Ommatidium Animals Drosophila Proteins Hedgehog Proteins Molecular Biology Hedgehog 030304 developmental biology Sex Characteristics 0303 health sciences Gene Expression Regulation Developmental RNA-Binding Proteins Cell Biology Compound eye Sex Determination Processes eye diseases DNA-Binding Proteins Sexual dimorphism Imaginal disc Evolutionary biology Eye development Drosophila Female sense organs Developmental biology 030217 neurology & neurosurgery Signal Transduction Developmental Biology |
| Zdroj: | Dev Biol |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2021.03.005 |
| Popis: | Understanding molecular mechanisms of sexually dimorphic organ growth is a fundamental problem of developmental biology. Recent quantitative studies showed that the Drosophila compound eye is a convenient model to study the determination of the final organ size. In Drosophila, females have larger eyes than males and this is evident even after correction for the larger body size. Moreover, female eyes include more ommatidia (photosensitive units) than male eyes and this difference is specified at the third larval instar in the eye primordia called eye imaginal discs. This may result in different visual capabilities between the two sexes and have behavioral consequences. Despite growing evidence on the genetic bases of eye size variation between different Drosophila species and strains, mechanisms responsible for within-species sexual dimorphism still remain elusive. Here, we discuss a presumptive crosstalk between the sex determination cascade and major signaling pathways during dimorphic eye development. Male- and female-specific isoforms of Doublesex (Dsx) protein are known to control sex-specific differentiation in the somatic tissues. However, no data on Dsx function during eye disc growth and patterning are currently available. Remarkably, Sex lethal (Sxl), the sex determination switch protein, was shown to directly affect Hedgehog (Hh) and Notch (N) signaling in the Drosophila wing disc. The similarity of signaling pathways involved in the wing and eye disc growth suggests that Sxl might be integrated into regulation of eye development. Dsx role in the eye disc requires further investigation. We discuss currently available data on sex-biased gene expression in the Drosophila eye and highlight perspectives for future studies. |
| Databáze: | OpenAIRE |
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