Comparative effect of nifedipine and S-adenosylmethionine, singly and in combination on experimental rat liver cirrhosis
| Autor: | Eugenio Pérez-Becerra, María J. Meniño, C. Cutrin, E. Barrio |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
S-Adenosylmethionine medicine.medical_specialty Cirrhosis Nifedipine Combination therapy chemistry.chemical_element Calcium Liver Cirrhosis Experimental General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics Ethanol business.industry Antagonist General Medicine Glutathione medicine.disease Rats Endocrinology chemistry Carbon tetrachloride Drug Therapy Combination business medicine.drug |
| Zdroj: | Life Sciences. 52:PL217-PL220 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(93)90050-d |
| Popis: | An experimental rat liver cirrhosis, by means of carbon tetrachloride and ethanol during 8 weeks, was employed to assay the effect of Nifedipine (a calcium antagonist blocker), S-Adenosylmethionine (a precursor of glutathione); singly and in combination on rat liver cirrhosis. A slight decrease of cirrhosis (N.S.) was observed with the pharmacological therapy employed singly. The combination therapy (Nifedipine+S-Adenosylmethionine) significantly inhibited liver cirrhosis (p < 0.01). |
| Databáze: | OpenAIRE |
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