Empyema thoracis secondary to community-acquired Panton-Valentine leukocidin (PVL) methicillin-resistant Staphylococcus aureus (MRSA) infection
| Autor: | Muhammad Badar Ganaie, Samira Mohd Afzal, Shahbaz Piracha, Syeda Saba Muneer Ahmed |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Methicillin-Resistant Staphylococcus aureus 0301 basic medicine medicine.medical_specialty medicine.drug_class Bacterial Toxins 030106 microbiology Antibiotics Leukocidin Exotoxins Thoracic Cavity medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Rare Disease Leukocidins Internal medicine medicine Humans 030212 general & internal medicine Empyema Pleural business.industry Septic shock General Medicine Middle Aged Staphylococcal Infections respiratory system biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus Empyema Community-Acquired Infections Pneumonia Staphylococcus aureus Panton–Valentine leukocidin business |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2018-228297 |
| Popis: | We report a case of a previously fit middle-aged man presenting to the outpatient setting with unilateral pleural effusion, with minimal symptoms. On subsequent investigations, he was diagnosed with empyema thoracis secondary to Panton-Valentine leukocidin (PVL)-toxin positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA). The patient was treated with prolonged antibiotics and pleural drainage, and he remained haemodynamically stable throughout hospital admission. PVL is a cytolytic exotoxin produced by some strains of S. aureus. Such strains often cause recurrent skin and soft tissue infections, usually in previously fit and healthy individuals. Less commonly, invasive infections occur; these carry a high mortality rate if associated with necrotising pneumonia or septic shock. PVL genes are present in approximately 2% of clinical isolates of S. aureus in the UK. PVL-producing MRSA infections are on the rise and present significant clinical and public health challenges. |
| Databáze: | OpenAIRE |
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