Influence of the long-term exposure to tartrazine and chlorophyll on the fibrogenic signalling pathway in liver and kidney of rats: the expression patterns of collagen 1-α, TGFβ-1, fibronectin, and caspase-3 genes

Autor:	Yasmina M. Abd-Elhakim, Gihan G. Moustafa, Khaled Abo-EL-Sooud, Abeer E. El-Metwally, M.M. Hashem, Haytham A. Ali
Rok vydání:	2019
Předmět:	Chlorophyll Male medicine.medical_specialty Health Toxicology and Mutagenesis Caspase 3 010501 environmental sciences Kidney 01 natural sciences Collagen Type I Transforming Growth Factor beta1 chemistry.chemical_compound Fibrosis Internal medicine medicine Animals Environmental Chemistry Tartrazine 0105 earth and related environmental sciences Creatinine biology Food Coloring Agents General Medicine medicine.disease Pollution Fibronectins Rats Fibronectin Collagen type I alpha 1 Endocrinology medicine.anatomical_structure Liver chemistry Apoptosis biology.protein Collagen Biomarkers
Zdroj:	Environmental Science and Pollution Research. 26:12368-12378
ISSN:	1614-7499 0944-1344
DOI:	10.1007/s11356-019-04734-w
Popis:	Colouring agents are highly present in diverse products in the human environment. We aimed to elucidate the fibrogenic cascade triggered by the food dyes tartrazine and chlorophyll. Rats were orally given distilled water, tenfold of the acceptable daily intake of tartrazine, or chlorophyll for 90 consecutive days. Tartrazine-treated rats displayed a significant rise (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c560991dc9eacfbd1194a9eb887d0e https://doi.org/10.1007/s11356-019-04734-w Zobrazit plný text záznamu Full text from SpringerLink