(1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria
| Autor: | Miroslava Rysova, Jana Hodačová, Michal Řezanka, Veronika Máková, Barbora Holubová, Jiří Brus, David Tetour |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
Polymers and Plastics Cyclohexane Pseudomonas aeruginosa Chemistry Pathogenic bacteria General Chemistry pseudomonas aeruginosa medicine.disease_cause sol-gel process Combinatorial chemistry Effective solution lcsh:QD241-441 chemistry.chemical_compound Antibiotic resistance lcsh:Organic chemistry Covalent bond Diamine medicine organo-bridged silsesquioxane electrospinning staphylococcus aureus organic-inorganic hybrids |
| Zdroj: | Polymers Volume 12 Issue 1 Polymers, Vol 12, Iss 1, p 206 (2020) |
| ISSN: | 2073-4360 |
| DOI: | 10.3390/polym12010206 |
| Popis: | An urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing > 99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability. |
| Databáze: | OpenAIRE |
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