| Autor: |
Wenzel, J., Haas, S. S., Dwyer, D. B., Ruef, A., Oeztuerk, O. F., Antonucci, L. A., von Saldern, S., Bonivento, C., Garzitto, M., Ferro, A., Paolini, M., Blautzik, J., Borgwardt, S., Brambilla, P., Meisenzahl, E., Salokangas, R. K. R., Upthegrove, R., Wood, S. J., Kambeitz, J., Koutsouleris, N., Kambeitz-Ilankovic, L., Sen Dong, M., Erkens, A., Gussmann, E., Haas, S., Hasan, A., Hoff, C., Khanyaree, I., Melo, A., Muckenhuber-Sternbauer, S., Kohler, J., Popovic, D., Penzel, N., Rangnick, A., Sanfelici, R., Spangemacher, M., Tupac, A., Urquijo, M. F., Weiske, J., Wosgien, A., Ruhrmann, S., Rosen, M., Betz, L., Haidl, T., Blume, K., Seves, M., Kaiser, N., Pilgram, T., Lichtenstein, T., Woopen, C., Andreou, C., Egloff, L., Harrisberger, F., Lenz, C., Leanza, L., Mackintosh, A., Smieskova, R., Studerus, E., Walter, A., Widmayer, S., Chisholm, K., Day, C., Griffiths, S. L., Iqbal, M., Lalousis, P., Pelton, M., Mallikarjun, P., Stainton, A., Lin, A., Denissoff, A., Ellila, A., Tiina From, R. N., Heinimaa, M., Ilonen, T., Jalo, P., Heikki Laurikainen, R. N., Lehtinen, M., Antti Luutonen, R. N., Makela, A., Paju, J., Pesonen, H., Armio (Saila), R. -L., Sormunen, E., Toivonen, A., Turtonen, O., Solana, A. B., Abraham, M., Hehn, N., Schirmer, T., Altamura, C., Belleri, M., Bottinelli, F., Re, M., Monzani, E., Percudani, M., Sberna, M., D'Agostino, A., Del Fabro, L., Menni, V. S. B., Perna, G., Nobile, M., Alciati, A., Balestrieri, M., Cabras, G., Fabbro, F., Piccin, S., Bertolino, A., Blasi, G., Pergola, G., Caforio, G., Faio, L., Quarto, T., Gelao, B., Romano, R., Andriola, I., Falsetti, A., Barone, M., Passatiore, R., Sangiuliano, M., Lencer, R., Surman, M., Bienek, O., Romer, G., Dannlowski, U., Schultze-Lutter, F., Schmidt-Kraepelin, C., Neufang, S., Korda, A., Rohner, H. |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Neuropsychopharmacology |
| ISSN: |
1740-634X |
| Popis: |
In schizophrenia, neurocognitive subtypes can be distinguished based on cognitive performance and they are associated with neuroanatomical alterations. We investigated the existence of cognitive subtypes in shortly medicated recent onset psychosis patients, their underlying gray matter volume patterns and clinical characteristics. We used a K-means algorithm to cluster 108 psychosis patients from the multi-site EU PRONIA (Prognostic tools for early psychosis management) study based on cognitive performance and validated the solution independently (N = 53). Cognitive subgroups and healthy controls (HC; n = 195) were classified based on gray matter volume (GMV) using Support Vector Machine classification. A cognitively spared (N = 67) and impaired (N = 41) subgroup were revealed and partially independently validated (Nspared = 40, Nimpaired = 13). Impaired patients showed significantly increased negative symptomatology (pfdr = 0.003), reduced cognitive performance (pfdr pfdr p = 0.01) separating impaired patients from HC revealed increases and decreases across several fronto-temporal-parietal brain areas, including basal ganglia and cerebellum. Cognitive and functional disturbances alongside brain morphological changes in the impaired subgroup are consistent with a neurodevelopmental origin of psychosis. Our findings emphasize the relevance of tailored intervention early in the course of psychosis for patients suffering from the likely stronger neurodevelopmental character of the disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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