A network meta-analysis on the effectiveness and safety of acupuncture in treating patients with major depressive disorder
| Autor: | Huang Weiyang, Hu Zhichao, Lam Wai Ching, Wang Zhiyu, Bian Zhao-Xiang, Li Huijuan, Zhong L. D. Linda, Yao Liang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty China Science Network Meta-Analysis Psychological intervention MEDLINE Acupuncture Therapy Therapeutics Cochrane Library Article 03 medical and health sciences 0302 clinical medicine Internal medicine Acupuncture medicine Humans 030212 general & internal medicine Depression (differential diagnoses) Data Management Depressive Disorder Major Multidisciplinary Depression medicine.disease Meta-analysis Medicine Major depressive disorder Female Reuptake inhibitor 030217 neurology & neurosurgery Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Acupuncture is an important alternative therapy in treating major depressive disorder (MDD), but its efficacy and safety are still not well assessed. This study is the first network meta-analysis exploring the effectiveness and safety of acupuncture, common pharmacological treatments or other non-medication therapies for MDD. Eight databases including PubMed, Embase, Allied and Complementary Medicine Database, Cochrane Library, Wan Fang Data, China National Knowledge Infrastructure, China Biology Medicine disc, and Chongqing VIP Database were searched up to Jan 17, 2021. Articles were screened and selected by two reviewers independently. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess the certainty of the evidence. A total of 71 eligible studies were included. The network analysis results indicated that the combined interventions of electro-acupuncture (EA) with selective serotonin reuptake inhibitors (SSRIs) and manual acupuncture (MA) with SSRIs were more effective in improving depression symptoms compared with acupuncture alone, pharmacological interventions alone, or other inactive groups. Among all the regimens, EA with SSRIs was found to have the highest effect in improving depression symptoms of MDD. In addition, there were slight differences in the estimations of the various treatment durations. The combination of acupuncture and serotonin-norepinephrine reuptake inhibitors (SNRIs) was found to be more effective than SNRIs alone. In conclusion, acupuncture and its combinations could be safe and effective interventions for MDD patients. EA with SSRIs seems to be the most effective intervention among the assessed interventions. Well-designed and large-scale studies with long-term follow-up should be conducted in the future. |
| Databáze: | OpenAIRE |
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