Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades
| Autor: | John E. Coia, Hans Linde Nielsen, Frank Møller Aarestrup, Turid Snekloth Søndergaard, Claus Østergaard, Ana Rita Rebelo, Dennis S. Hansen, Michael Kemp, Pimlapas Leekitcharoenphon, Henrik Westh, Bent Røder, Judit Szarvas, Niels Nørskov-Lauritsen, Valeria Bortolaia, Niels Frimodt-Møller |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Fungal infection QH301-705.5 Population Plant Science Genome Microbiology antifungal susceptibility Biology (General) Clade Candida albicans education Ecology Evolution Behavior and Systematics Whole genome sequencing education.field_of_study Whole-genome sequencing biology Candida glabrata Communication fungal infection biology.organism_classification bacterial infections and mycoses Corpus albicans phylogenetics Phylogenetics whole-genome sequencing Echinocandins Antifungal susceptibility |
| Zdroj: | Szarvas, J, Rebelo, A R, Bortolaia, V, Leekitcharoenphon, P, Hansen, D S, Nielsen, H L, Nørskov-Lauritsen, N, Kemp, M, Røder, B L, Frimodt-Møller, N, Søndergaard, T S, Coia, J E, Østergaard, C, Westh, H & Aarestrup, F M 2021, ' Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades ', Journal of Fungi, vol. 7, no. 11, 962 . https://doi.org/10.3390/jof7110962 Journal of Fungi Szarvas, J, Rebelo, A R, Bortolaia, V, Leekitcharoenphon, P, Hansen, D S, Nielsen, H L, Nørskov-Lauritsen, N, Kemp, M, Røder, B L, Frimodt-Møller, N, Søndergaard, T S, Coia, J E, Østergaard, C, Westh, H & Aarestrup, F M 2021, ' Danish whole-genome-sequenced candida albicans and candida glabrata samples fit into globally prevalent clades ', Journal of Fungi, vol. 7, no. 11, 962 . https://doi.org/10.3390/jof7110962 Journal of Fungi, Vol 7, Iss 962, p 962 (2021) Szarvas, J, Rebelo, A R, Bortolaia, V, Leekitcharoenphon, P, Schrøder Hansen, D, Nielsen, H L, Nørskov-Lauritsen, N, Kemp, M, Røder, B L, Frimodt-Møller, N, Søndergaard, T S, Coia, J E, Østergaard, C, Westh, H & Aarestrup, F M 2021, ' Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades ', Journal of fungi (Basel, Switzerland), vol. 7, no. 11, 962 . https://doi.org/10.3390/jof7110962 Szarvas, J, Rebelo, A R, Bortolaia, V, Leekitcharoenphon, P, Hansen, D S, Nielsen, H L, Nørskov-Lauritsen, N, Kemp, M, Røder, B L, Frimodt-Møller, N, Søndergaard, T S, Coia, J, Østergaard, C, Westh, H & Aarestrup, F M 2021, ' Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades ', Journal of Fungi, vol. 7, no. 11, 962 . https://doi.org/10.3390/jof7110962 Szarvas, J, Rebelo, A R, Bortolaia, V, Leekitcharoenphon, P, Hansen, D S, Nielsen, H L, Nørskov-Lauritsen, N, Kemp, M, Røder, B L, Frimodt-Møller, N, Søndergaard, T S, Coia, J E, Østergaard, C, Westh, H & Aarestrup, F M 2021, ' Danish whole-genome-sequenced Candida albicans and Candida glabrata samples fit into globally prevalent clades ', Journal of Fungi, vol. 7, no. 11, 962 . https://doi.org/10.3390/jof7110962 |
| DOI: | 10.3390/jof7110962 |
| Popis: | Candida albicans and Candida glabrata are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the Candida population in the country. The majority of the 30 C. albicans isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight C. glabrata isolates were predicted to be prevalent subtypes. Antifungal susceptibility testing proved all C. albicans isolates to be susceptible to both azoles and echinocandins. Two C. glabrata isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species. |
| Databáze: | OpenAIRE |
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