A Controversial New Approach to Address Hematological Parameters in Hashimoto's Thyroiditis
| Autor: | Hayrullah Yazar, Ihsan Hakki Ciftci, Gönül Gürol, Ali Tamer, Aysel Gurkan Tocoglu, Dilek Arpaci, Hasan Ergenç |
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| Přispěvatelé: | Arpaci, D, Gurol, G, Ergenc, H, Yazar, H, Tocoglu, AG, Ciftci, IH, Tamer, A, Sakarya Üniversitesi/Sağlık Hizmetleri Meslek Yüksekokulu, Gürol Çiftci, Gönül, Yazar, Hayrullah, Çiftci, İhsan Hakkı, Tamer, Ali, Zonguldak Bülent Ecevit Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Thyrotropin Hashimoto Disease Thyroid Function Tests 030204 cardiovascular system & hematology Thyroid function tests Hashimoto's General Biochemistry Genetics and Molecular Biology Thyroiditis Autoimmune Diseases Leukocyte Count 03 medical and health sciences 0302 clinical medicine Thyroid-stimulating hormone Internal medicine 0502 economics and business medicine Humans Euthyroid Lymphocyte Count Lymphocytes Mean platelet volume Analysis of Variance medicine.diagnostic_test Platelet Count business.industry 05 social sciences Thyroid fungi Case-control study medicine.disease body regions Thyroxine Medical Laboratory Technology Neutrophil lymphocyte ratio C-Reactive Protein medicine.anatomical_structure Endocrinology Case-Control Studies thyroiditis Female 050211 marketing Thyroid function business Mean Platelet Volume |
| Popis: | Background: Hashimoto's thyroiditis (HT) is a common autoimmune disorder. Genetic, environmental, and immunological factors all play a role in the pathogenesis of HT, but the effects of lymphocytes and platelets on the pathophysiology of HT are still unknown. In this study, we evaluated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in HT groups and HT subgroups with low cardiovascular risks. Methods: This study included 92 patients with HT and 38 control subjects. Among the HT patients, three subgroups were formed according to thyroid function: overt (n = 12), subclinical (n = 38), and euthyroid (normally functioning thyroid; n = 42). Results: Age and gender distributions were similar between the patient and control groups. Body mass index was higher in the patient group than in the control group. The C reactive protein level was higher in patients than controls (p = 0.064). The thyroid stimulating hormone (TSH) level was higher and the mean free thyroxine level lower in the patient group than in the control group (p < 0.05). There were no differences between the groups with regard to leukocytes, neutrophils, platelets, or MPV (p > 0.05). The NLR and PLR were significantly different in one subgroup of HT patients relative to healthy subjects (p < 0.05). However, we did not find any statistical differences in the MPV among the three subgroups (p = 0.547). A positive correlation was found among the NLR, anti-thyroglobulin (TG) antibodies, and anti-thyroid peroxidase (TPO) antibodies (p < 0.01), although there was a negative correlation between the PLR, TSH, anti-TPO, and anti-TG (p < 0.001). Conclusions: A single marker or panel of biomarkers is not a consistent indicator of HT, but NLR combined with PLR testing may offer a more reliable diagnosis. © 2016, Verlag Klinisches Labor GmbH. All rights reserved. |
| Databáze: | OpenAIRE |
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