Obesity in patients with COVID-19: a systematic review and meta-analysis

Autor: Yi Huang, Yi Sui, Wei Ling, Yao Lu, Hai-Lu Zhao, Min Wang, Yan-Mei Huang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
BMI
body mass index
MeSH
Medical Subject Headings
030209 endocrinology & metabolism
ACE2
angiotensin-converting enzyme 2
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Article
law.invention
SMD
standardized mean difference
03 medical and health sciences
0302 clinical medicine
Endocrinology
CNKI
Chinese National Knowledge Infrastructure
law
Intensive care
Internal medicine
NOS
Newcastle-Ottawa Scale
medicine
Obesity
Invasive mechanical ventilation
Mortality
Univariate analysis
Coronavirus disease 2019
business.industry
SAT
subcutaneous adipose tissue
Odds ratio
medicine.disease
Intensive care unit
ICU
intensive care unit
CT
computed tomography
OR
odds ratio
030104 developmental biology
IMV
invasive mechanical ventilation
IAV
Influenza A virus
Visceral adipose tissue
Meta-analysis
COVID-19
Coronavirus Disease 2019
DKD
diabetic kidney disease
business
VAT
Visceral adipose tissue
95%CI
95% confidence interval
Body mass index
Cohort study
Zdroj: Metabolism
ISSN: 1532-8600
0026-0495
Popis: Background Obesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes of COVID-19 warrant systematical investigation. Objective This study explores the effects of obesity with the risk of severe disease among patients with COVID-19. Methods Body mass index (BMI) and degree of visceral adipose tissue (VAT) accumulation were used as indicators for obesity status. Publication databases including preprints were searched up to August 10, 2020. Clinical outcomes of severe COVID-19 included hospitalization, a requirement for treatment in an intensive care unit (ICU), invasive mechanical ventilation (IMV), and mortality. Risks for severe COVID-19 outcomes are presented as odds ratios (OR) and 95% confidence interval (95%CI) for cohort studies with BMI-defined obesity, and standardized mean difference (SMD) and 95%CI for controlled studies with VAT-defined excessive adiposity. Results A total of 45, 650 participants from 30 studies with BMI-defined obesity and 3 controlled studies with VAT-defined adiposity were included for assessing the risk of severe COVID-19. Univariate analyses showed significantly higher ORs of severe COVID-19 with higher BMI: 1.76 (95%: 1.21, 2.56, P = 0.003) for hospitalization, 1.67 (95%CI: 1.26, 2.21, P
Highlights • Obesity increases risk for hospitalization among patients with COVID-19. • Obesity increases risk for needing ICU admission among patients with COVID-19. • Obesity increases risk for requiring IMV support among patients with COVID-19. • Obesity increases risk for death among patients with COVID-19. • Excessive visceral adiposity appears to be associated with severe COVID-19 outcomes.
Databáze: OpenAIRE
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