Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

Autor: Carlos López-Otín, Francesca Castoldi, Elena Sierra-Filardi, Federico Pietrocola, Clea Bárcena, Gemma G. Martínez-García, Guido Kroemer, Lorena Esteban, Álvaro F. Fernández, María F. Suárez, Guillermo Mariño, Isaac Tamargo-Gómez, Patricia Boya
Přispěvatelé: Universidad de Oviedo [Oviedo], Université Paris Descartes - Paris 5 (UPD5), Sotio a.c., Centro de Investigaciones Biológicas (CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Service de biologie [CHU HEGP], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Européen Georges Pompidou [APHP] (HEGP)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Cancer Research
medicine.medical_specialty
Programmed cell death
medicine.medical_treatment
Immunology
Autophagy-Related Proteins
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Biology
Diabetes Mellitus
Experimental
03 medical and health sciences
Cellular and Molecular Neuroscience
Mice
Weight loss
Internal medicine
Insulin-Secreting Cells
medicine
[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Adipocytes
Autophagy
Animals
Obesity
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Mice
Knockout
Cell Death
Insulin
Cell Biology
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Streptozotocin
medicine.disease
3. Good health
Diet
Fatty Liver
Cysteine Endopeptidases
030104 developmental biology
Endocrinology
Lipotoxicity
Original Article
medicine.symptom
Steatosis
Weight gain
medicine.drug
Zdroj: Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2017, 8, pp.e2970. ⟨10.1038/cddis.2017.373⟩
Cell Death & Disease
Scopus
Cell Death and Disease, Nature Publishing Group, 2017, 8, pp.e2970. 〈10.1038/cddis.2017.373〉
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
ISSN: 2041-4889
DOI: 10.1038/cddis.2017.373⟩
Popis: GK is supported by the Ligue contre le Cancer (équipe labelisée); Agence National de la Recherche (ANR); Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Institut National du Cancer (INCa); Fondation Bettencourt-Schueller; Fondation de France; Fondation pour la Recherche Médicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). PB is supported by a SAF2012-36079 and CDS2010-00045 grants from MINECO, Spain. GM is funded by the Ramon y Cajal Program (RYC-2013-12751) and supported by Spain’s Ministerio de Economía y Competitividad, BFU2015-68539 and the BBVA foundation, BBM_BIO_3105. GM and GK are guarantors of the work presented herein
Fernández, Á.F., Bárcena, C., Martínez-García, G.G., Tamargo-Gómez, I., Suárez, M.F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., López-Otín, C., Kroemer, G., Mariño, G.
Databáze: OpenAIRE
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