Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function: An iPOWER substudy

Autor: Jens Kastrup, Ida Gustafsson, Peter Riis Hansen, Adam Pena, Naja Dam Mygind, Eva Prescott, Henrik Steen Hansen, Daria Frestad Bechsgaard, Nis Høst, Jens D. Hove, Marie Mide Michelsen
Rok vydání: 2020
Předmět:
Zdroj: Bechsgaard, D F, Hove, J D, Michelsen, M M, Mygind, N D, Pena, A, Hansen, P R, Hansen, H S, Kastrup, J, Høst, N, Gustafsson, I & Prescott, E 2021, ' Myocardial CT perfusion compared with transthoracic Doppler echocardiography in evaluation of the coronary microvascular function : An iPOWER substudy ', Clinical Physiology and Functional Imaging, vol. 41, no. 1, pp. 85-94 . https://doi.org/10.1111/cpf.12669
ISSN: 1475-097X
1475-0961
DOI: 10.1111/cpf.12669
Popis: BackgroundA significant number of women with angina and no obstructive coronary artery disease (CAD; MethodsStatic CTP with adenosine-induced vasodilation and TTDE of the left anterior descending artery with dipyridamole-induced vasodilation were successfully performed and analysed in 99 women with stable angina and no obstructive CAD and 33 asymptomatic women with no obstructive CAD. CMD was defined as CFVR < 2.ResultsCorrelation between rate-pressure product corrected MPR and CFVR was weak but significant (r = .23; p = .007). MPR was highest among asymptomatic women with normal CFVR (median [interquartile range; IQR] 158 [145–181] %). Symptomatic women with normal CFVR had reduced MPR (148 [134–162] %; age-adjusted p < .001); however, the lowest MPR was found in symptomatic women with CMD (140 [129–164] %; age-adjusted p < .001), independent of cardiovascular risk factors and haemodynamic parameters (p = .017).ConclusionWomen with angina, CMD and no obstructive CAD had markedly diminished MPR compared with asymptomatic women. Correlation between CFVR and MPR was weak, suggesting that CTP and TTDE are not interchangeable for detection of CMD.
Databáze: OpenAIRE
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