Epidemic dengue 2 in the city of Djibouti 1991-1992
| Autor: | C. Bruce Cropp, Jean-Pierre Parra, Guénaël R. Kodier, Duane J. Gubler, Ray R. Arthur, Mohamed A. Abdourhaman, Atef K. Soliman, Dominique Polycarpe, Stanton E. Cope, Jérôme Maslin |
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| Rok vydání: | 1996 |
| Předmět: |
Zika virus disease
Adult Male Adolescent viruses Aedes aegypti Biology Antibodies Viral Dengue fever Zika virus Disease Outbreaks Dengue Aedes Seroepidemiologic Studies medicine Animals Humans Flavivirus Infections Prospective Studies Child Retrospective Studies Flavivirus Yellow fever Public Health Environmental and Occupational Health Infant General Medicine Middle Aged medicine.disease biology.organism_classification Virology Infectious Diseases Child Preschool Djibouti Parasitology Female |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 90(3) |
| ISSN: | 0035-9203 |
| Popis: | From October 1991 to February 1992, an outbreak of acute fever (in which thick blood films were negative for malaria) spread rapidly in the city of Djibouti, Djibouti Republic, affecting all age groups and both nationals and foreigners. The estimated number of cases was 12,000. The clinical features were consistent with a non-haemorrhagic dengue-like illness. Serum samples from 91 patients were analysed serologically for flavivirus infection (dengue 1-4, West Nile, yellow fever, Zika, Banzi, and Uganda-S), and virus isolation was attempted. Twelve strains of dengue 2 virus were isolated. Dengue infection was confirmed by a 4-fold or greater rise in immunoglobulin (Ig) G antibody in paired serum specimens, the presence of IgM antibody, or isolation of the virus. Overall, 46 of the suspected cases (51%) were confirmed virologically or had serological evidence of a recent flavivirus infection. Statistical analysis showed that the presence of a rash was the best predictor of flavivirus seropositivity. In November 1992, Aedes aegypti was widespread and abundant in several districts of Djibouti city. A serological study of serum samples collected from Djiboutian military personnel 5 months before the epidemic showed that only 15/177 (8.5%) had flavivirus antibodies. These findings, together with a negative serosurvey for dengue serotypes 1-4 and yellow fever virus performed in 1987, support the conclusion that dengue 2 virus has only recently been introduced to Djibouti. |
| Databáze: | OpenAIRE |
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