Dynamic Routing of Task-relevant Signals for Decision Making in Dorsolateral Prefrontal Cortex
| Autor: | Christopher H. Donahue, Daeyeol Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Computer science Prefrontal Cortex Sensory system Mnemonic behavioral disciplines and activities Choice Behavior Article 03 medical and health sciences 0302 clinical medicine Reward medicine Premovement neuronal activity Animals Prefrontal cortex 030304 developmental biology Self-reference effect 0303 health sciences Behavior Animal Working memory General Neuroscience Macaca mulatta Dorsolateral prefrontal cortex medicine.anatomical_structure Memory Short-Term nervous system Visual Perception Probability Learning Consumer neuroscience Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes Psychomotor Performance |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Neurons in the dorsolateral prefrontal cortex (DLPFC) encode a diverse array of sensory and mnemonic signals, but little is known about how this information is dynamically routed during decision making. We analyzed the neuronal activity in the DLPFC of monkeys performing a probabilistic reversal task where information about the probability and magnitude of reward was provided by the target color and numerical cues, respectively. The location of the target of a given color was randomized across trials and therefore was not relevant for subsequent choices. DLPFC neurons encoded signals related to both task-relevant and irrelevant features, but only task-relevant mnemonic signals were encoded congruently with choice signals. Furthermore, only the task-relevant signals related to previous events were more robustly encoded following rewarded outcomes. Thus, multiple types of neural signals are flexibly routed in the DLPFC so as to favor actions that maximize reward. |
| Databáze: | OpenAIRE |
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