THYROID DYSFUNCTION AND BLOOD PRESSURE COMPONENTS: MULTIVARIATE STATISTICAL ASSOCIATIONS
| Autor: | L. J. Majella, M. Grootveld, Ponniah Thirumalaikolundusubramaniana, E. Nithya, Ramachandran Meenakshisundarama |
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| Rok vydání: | 2014 |
| Předmět: |
endocrine system
medicine.medical_specialty Multivariate statistics endocrine system diseases business.industry Thyroid disease Thyroid Univariate medicine.disease Gastroenterology Blood pressure Endocrinology medicine.anatomical_structure Internal medicine medicine Biomarker (medicine) Analysis of variance business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Journal of Medical and Clinical Research. 5:294-304 |
| ISSN: | 0976-5549 0976-5530 |
| Popis: | Materials and Methods: We followed rigid criteria in order to select adults with hyperthyroidism (n=71) and hypothyroidism (n=300), together with healthy age-matched controls (n =300), and applied a series of statistical analysis strategies to the datasets acquired. Results: Univariate statistical analysis strategies of the SBP:DBP ratio by ANOVA and ANCOVA revealed that its mean value was significantly greater in hyperthyroid patients than those of healthy control and hypothyroid subjects (p˂0.0001). Body mass index (BMI) was significantly elevated in hypothyroid patients over those of healthy control and hyperthyroid subjects (p˂0.0001); healthy controls had a significantly greater BMI value than that of hyperthyroid patients (p˂0.0001). Multivariate (MV) analysis [redundancy analysis (RDA), canonical correlation analysis (CCorA), and principal component analysis (PCA)] demonstrated powerful relationships between all blood pressure components and thyroid disease classifications, together with their biomarker indices and further patient-related parameters. Conclusions: Since thyroid dysfunctional status is associated with elevated BP, and increasing BP is positively-correlated with elevated serum thyroid biomarkers, hyper and hypothyroid disorders should be recognized and treated early in order to avoid critical hazards presented by high BP. |
| Databáze: | OpenAIRE |
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