Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template

Autor:	Shelley Darnbrough, John W. Ullrich, Richard Labaudiniere, Kent Neuenschwander, Robert L. Morris, Groneberg Robert D, Jane Kline, Matthew M. Morrissette, and Anthony C. Scotese, Stevan W. Djuric, Stephen M. Condon, Christopher J. Burns, Gerard McGeehan
Rok vydání:	1999
Předmět:	Matrix metalloproteinase inhibitor Stereochemistry Phosphodiesterase Inhibitors Guinea Pigs Matrix metalloproteinase Matrix Metalloproteinase Inhibitors Hydroxamic Acids Chemical synthesis Sulfone chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Structure–activity relationship Animals Protease Inhibitors Sulfones chemistry.chemical_classification Hydroxamic acid biology Macrophages Metalloendopeptidases Fibroblasts Cyclic Nucleotide Phosphodiesterases Type 4 Enzyme chemistry Enzyme inhibitor 3' 5'-Cyclic-AMP Phosphodiesterases Gelatinases biology.protein Molecular Medicine Matrix Metalloproteinase 2 Matrix Metalloproteinase 1
Zdroj:	Journal of medicinal chemistry. 42(4)
ISSN:	0022-2623
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603085b1d951a423b31828201dd7ea7e https://pubmed.ncbi.nlm.nih.gov/10052961 Zobrazit plný text záznamu