Bias towards dementia: Are hip fracture trials excluding too many patients?
| Autor: | Hebert-Davies, J., Laflamme, G.Y., Rouleau, D., Schreurs, B.W., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraidts, L., Gardeniers, J.W.M., Tan, E.C.T.H., Poekhekke, L.M.S.J., Waal Malefijt, M.C. de |
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| Přispěvatelé: | Emergency Medicine, Surgery, Radiology & Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Canada medicine.medical_specialty MEDLINE India Poison control Comorbidity Arthroscopy Quality of life Surveys and Questionnaires Injury prevention medicine Humans Dementia Cognitive Dysfunction Geriatric Assessment Selection Bias Aged Netherlands General Environmental Science Aged 80 and over Geriatrics Human Movement & Fatigue [NCEBP 10] Clinical Trials as Topic Hip fracture Hip Fractures Norway business.industry Patient Selection Australia medicine.disease United States Human Movement & Fatigue Tissue engineering and pathology [NCEBP 10] Evaluation of complex medical interventions [NCEBP 2] Quality of Life Physical therapy General Earth and Planetary Sciences Female Evaluation of complex medical interventions Tissue engineering and pathology [NCEBP 2] business Prejudice |
| Zdroj: | Injury : International Journal of the Care of the Injured, 43, 1978-84 Injury : International Journal of the Care of the Injured, 43, 12, pp. 1978-84 Injury, 43(12), 1978-84 Injury-International Journal of the Care of the Injured, 43(12), 1978-1984. Elsevier Ltd. |
| ISSN: | 1879-0267 0020-1383 |
| Popis: | Patients with hip fractures are older and often present many co-morbidities, including dementia.These patients cannot answer quality of life questionnaires and are generally excluded from trials.We hypothesized that a significant number of patients are being excluded from these studies and thismay impact outcomes. This was a two part study; the first analyzing databases of two ongoing large-scale multi-centred hip fracture trials and the second being a systematic review. The FAITH andHEALTH studies were analyzed for exclusion incidence directly related to dementia. The second partconsisted of a systematic search of all relevant studies within the last 20 years. In the FAITH study, atotal of 1690 subjects were excluded, 375 (22.2%) of which were due to dementia or cognitiveimpairment. In the HEALTH study, 575 were excluded with dementia/cognitive impairmentrepresenting 207 patients (36%). Following the systematic review, 251 articles were identified 17 ofwhich were retained. The overall prevalence of dementia was 27.9% (range 2–51%). Only two studiescompared demented and non-demented groups. In these studies significant increases in bothmortality and complications were found. In summary, when investigating hip fractures, choosingappropriate objective endpoints is essential to ensure results are also applicable to patients withdementia. |
| Databáze: | OpenAIRE |
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