Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease
| Autor: | Barry Crook, Suzanna J. Newman, Peter R. Maycox, Brian C Bond, John Darker, Colin Edge |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Receptors Steroid Central nervous system Receptors Cytoplasmic and Nuclear Apoptosis Disease Biology Degenerative disease Alzheimer Disease medicine Nuclear Receptor Subfamily 4 Group A Member 1 Craniocerebral Trauma Humans Receptor Molecular Biology Stroke Aged Aged 80 and over Neurons Receptors Thyroid Hormone General Neuroscience Neurodegeneration Brain Neurodegenerative Diseases Middle Aged medicine.disease Immunohistochemistry DNA-Binding Proteins medicine.anatomical_structure Immunology Female Neurology (clinical) Neuron Alzheimer's disease Neuroscience Developmental Biology Transcription Factors |
| Zdroj: | Brain research. 857(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from Alzheimer's disease (AD), stroke and neurotrauma patients, using a novel anti-peptide antibody generated to an exposed epitope in the extracellular domain of the receptor. We show a statistically significant increase in TR3 protein levels in AD brain samples but not in stroke, neurotrauma or control samples. The increase observed for TR3 was specific to neurons in regions associated with AD pathology. This is the first report describing the neuron-specific regulation of a death receptor in chronic disease and may indicate that a TR3 receptor-mediated signalling pathway is involved in AD-associated neuronal loss. |
| Databáze: | OpenAIRE |
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