Enkephalinase inhibition and precursor amino acid loading improves inpatient treatment of alcohol and polydrug abusers: Double-blind placebo-controlled study of the nutritional adjunct SAAVE™
| Autor: | C E Elliott, A I Samuels, L Cataldie, Kenneth Blum, M C Trachtenberg, R L Sexton, M L Dingler |
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| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Health (social science) Substance-Related Disorders Diet therapy Statistics as Topic Placebo-controlled study Pharmacology Toxicology Placebo Biochemistry law.invention Placebos Behavioral Neuroscience Neurochemical Double-Blind Method Randomized controlled trial law Detoxification medicine Humans Prodrugs Amino Acids Psychiatry Food Formulated Clinical Trials as Topic business.industry Enkephalinase Galvanic Skin Response General Medicine medicine.disease Hospitalization Substance abuse Alcoholism Neurology Neprilysin business |
| Zdroj: | Alcohol. 5:481-493 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(88)90087-0 |
| Popis: | We investigated the effects of the amino acid and vitamin mixture SAAVE in inpatient, chemically-dependent subjects to evaluate the role of neurotransmitters in facilitating recovery and adjustment to a detoxified, sober state. SAAVE is formulated from amino acids that are precursors for neurotransmitters and neuromodulators thought to be involved in alcohol and drug seeking behavior. In a double-blind, placebo-controlled, randomized study of 62 alcoholics and polydrug abusers, SAAVE patients had a significantly reduced stress response as measured by the skin conductance level (SCL), and significantly improved Physical Scores and BESS Scores (behavioral, emotional, social and spiritual). After detoxification there was a six-fold decrease in AMA rates when comparing SAAVE vs. placebo groups. In this inpatient treatment experience SAAVE facilitated the rate of recovery and allowed patients to respond more fully and more quickly to the behavioral goals of the program, for example as measured by the BESS Score. The use of SAAVE to achieve enkephalinase inhibition and precursor amino acid loading in the acute inpatient treatment environment provides the practitioner with the potential ability to restore the neurochemical changes inherent to alcoholism and drug abuse. These findings increase our understanding of the clinically relevant neurobiological mechanisms which underlie compulsive disease. |
| Databáze: | OpenAIRE |
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