The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF
| Autor: | Emma Buzzigoli, Manuela Scali, Alessia Dattilo, Amalia Gastaldelli, Giovanni Ceccarini, Paolo Vitti, Marco Mainardi, Ilaria Barone, Margherita Maffei, Tommaso Pizzorusso, Ferruccio Santini, Lamberto Maffei, Gaia Scabia |
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| Přispěvatelé: | Scabia, Gaia, Barone, Ilaria, Mainardi, Marco, Ceccarini, Giovanni, Scali, Manuela, Buzzigoli, Emma, Dattilo, Alessia, Vitti, Paolo, Gastaldelli, Amalia, Santini, Ferruccio, Pizzorusso, Tommaso, Maffei, Lamberto, Maffei, Margherita |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Leptin Male medicine.medical_specialty animal structures food intake Adipose Tissue White lcsh:Medicine Adipose tissue Stimulation White adipose tissue Tropomyosin receptor kinase B Weight Gain Settore BIO/09 - Fisiologia Article STAT3 03 medical and health sciences Mice 0302 clinical medicine Internal medicine Fluoxetine medicine Animals Receptor trkB SSRI Obesity lcsh:Science Brain-derived neurotrophic factor Multidisciplinary Chemistry Brain-Derived Neurotrophic Factor lcsh:R Body Weight brown adipose tissue Antidepressive Agents Mice Inbred C57BL 030104 developmental biology Endocrinology high-fat diet BDNF Hypothalamus lcsh:Q serotonin diet hypothalamus medicine.symptom Energy Metabolism Weight gain 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) |
| Popis: | Leptin and Brain Derived Neurotrophic Factor (BDNF) pathways are critical players in body weight homeostasis. Noninvasive treatments like environmental stimulation are able to increase response to leptin and induce BDNF expression in the brain. Emerging evidences point to the antidepressant selective serotonin reuptake inhibitor Fluoxetine (FLX) as a drug with effects similar to environmental stimulation. FLX is known to impact on body weight, with mechanisms yet to be elucidated. We herein asked whether FLX affects energy balance, the leptin system and BDNF function. Adult lean male mice chronically treated with FLX showed reduced weight gain, higher energy expenditure, increased sensitivity to acute leptin, increased hypothalamic BDNF expression, associated to changes in white adipose tissue expression typical of “brownization”. In the Ntrk2tm1Ddg/J model, carrying a mutation in the BDNF receptor Tyrosine kinase B (TrkB), these effects are partially or totally reversed. Wild type obese mice treated with FLX showed reduced weight gain, increased energy output, and differently from untreated obese mice, a preserved acute response to leptin in terms of activation of the intracellular leptin transducer STAT3. In conclusion, FLX impacts on energy balance and induces leptin sensitivity and an intact TrkB function is required for these effects to take place. |
| Databáze: | OpenAIRE |
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