A perspective on synthetic and solid-form enablement of inhalation candidates

Autor:	Dannielle Frances Roberts, Pieter D. de Koning, Matthew D. Selby
Rok vydání:	2011
Předmět:	Dosage Forms Pharmacology Active ingredient Design stage Computer science Chemistry Pharmaceutical Nanotechnology Chemist High complexity Administration Inhalation Drug Discovery Molecular Medicine Biochemical engineering Powders
Zdroj:	Future Medicinal Chemistry. 3:1679-1701
ISSN:	1756-8927 1756-8919
DOI:	10.4155/fmc.11.125
Popis:	The administration of compounds by a dry-powder inhaler presents significant challenges to the development and discovery chemist, owing to the stringent requirements placed upon the physical characteristics of the active pharmaceutical ingredient and the high complexity of the molecules concerned. The current state of synthetic chemistry technology is such that commercial syntheses of these compounds are demanding but achievable. While synthetic chemistry will remain a major component of the development of inhaled therapies, the main challenge facing practitioners in this area is the early identification of a suitable solid form. Further advances in the prediction of solid-form properties would significantly enable this field and may allow triage of molecules to be carried out at the design stage of projects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd38e06c247f817054042ed2ce5334e https://doi.org/10.4155/fmc.11.125 Zobrazit plný text záznamu