Fast Compensatory Functional Network Changes Caused by Reversible Inactivation of Monkey Parietal Cortex
| Autor: | Guy Orban, Claire Wardak, Qi Zhu, Hauke Kolster, Annelies Gerits, Wim Vanduffel, Puiu F. Balan |
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| Přispěvatelé: | Laboratorium voor Neuro- en Psychofysiologie, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
genetic structures Cognitive Neuroscience Posterior parietal cortex Macaque 050105 experimental psychology Functional networks 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Parietal Lobe biology.animal Lateral intraparietal cortex Cortex (anatomy) Attention network Neural Pathways medicine Animals 0501 psychology and cognitive sciences GABA-A Receptor Agonists ComputingMilieux_MISCELLANEOUS Visual search visual search biology Muscimol fMRI 05 social sciences Recovery of Function Adaptation Physiological Macaca mulatta Magnetic Resonance Imaging LIP muscimol medicine.anatomical_structure chemistry Excitatory postsynaptic potential [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] sense organs Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex Cerebral Cortex, Oxford University Press (OUP), 2019, 29 (6), pp.2588-2606. ⟨10.1093/cercor/bhy128⟩ |
| ISSN: | 1047-3211 1460-2199 |
| Popis: | The brain has a remarkable capacity to recover after lesions. However, little is known about compensatory neural adaptations at the systems level. We addressed this question by investigating behavioral and (correlated) functional changes throughout the cortex that are induced by focal, reversible inactivations. Specifically, monkeys performed a demanding covert spatial attention task while the lateral intraparietal area (LIP) was inactivated with muscimol and whole-brain fMRI activity was recorded. The inactivation caused LIP-specific decreases in task-related fMRI activity. In addition, these local effects triggered large-scale network changes. Unlike most studies in which animals were mainly passive relative to the stimuli, we observed heterogeneous effects with more profound muscimol-induced increases of task-related fMRI activity in areas connected to LIP, especially FEF. Furthermore, in areas such as FEF and V4, muscimol-induced changes in fMRI activity correlated with changes in behavioral performance. Notably, the activity changes in remote areas did not correlate with the decreased activity at the site of the inactivation, suggesting that such changes arise via neuronal mechanisms lying in the intact portion of the functional task network, with FEF a likely key player. The excitation–inhibition dynamics unmasking existing excitatory connections across the functional network might initiate these rapid adaptive changes. ispartof: CEREBRAL CORTEX vol:29 issue:6 pages:2588-2606 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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