A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea
| Autor: | Joana Marto, Ana M. Martins, Jodi L. Johnson, Emmy M. Graber |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.drug_class Antibiotics Review RM1-950 Azithromycin Biochemistry Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences minocycline 0302 clinical medicine Clarithromycin medicine acne vulgaris Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Adverse effect Acne tetracycline business.industry Clindamycin Minocycline medicine.disease Dermatology rosacea Infectious Diseases Rosacea Therapeutics. Pharmacology business medicine.drug |
| Zdroj: | Antibiotics, Vol 10, Iss 757, p 757 (2021) Antibiotics |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics10070757 |
| Popis: | Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne (topical erythromycin and clindamycin and, more recently, topical azithromycin and clarithromycin) has been steadily increasing and new topical antibiotics are needed. Minocycline is a semisynthetic tetracycline-derived antibiotic currently used systemically to treat a wide range of infections caused by Gram-negative and Gram-positive bacteria. In addition to its antibiotic activity, minocycline possesses anti-inflammatory properties, such as the downregulation of proinflammatory cytokine production, suppression of neutrophil chemotaxis, activation of superoxide dismutase, and inhibition of phagocytosis, among others. These characteristics make minocycline a valuable agent for treatment of dermatological diseases such as acne vulgaris and papulopustular rosacea. However, more frequent or serious adverse effects have been observed upon the systemic administration of minocycline than with other tetracyclines. Examples of serious adverse effects include hypersensitivity syndrome reaction, drug-induced lupus, idiopathic intracranial hypertension, and other autoimmune syndromes that may cause death. Here, we review adverse effects and drug–drug interactions observed with oral administration of minocycline and contrast this with topical minocycline formulations recently approved or under development for effectively treating dermatological disorders with fewer adverse effects and less drug interaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|