Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Autor: Jason F. Huntley, Lloyd S. Miller, Preeti Shahi, Michail Kotsyfakis, Adela S. Oliva Chávez, Eileen M. Barry, Laura Santambrogio, Daniel E. Sonenshine, Choukri Ben Mamoun, Holly L. Hammond, Steven M. Jay, Shelby L Ford, L. Rainer Butler, Kateryna Morozova, Utpal Pal, Brandi E. Hobbs, Dana K. Shaw, Glen A. Scoles, Joao H. F. Pedra, Xiaowei Wang, Amanda D. Buskirk, Cristina C. Clement, Brenden G. Tully, Jesus G. Valenzuela, Liron Marnin, Nathan K. Archer, Michael Levin, Anya J.O’ Neal, Marcela F. Pasetti, Erin E.Mc Clure Carroll, Kathleen L. Mason, Marcelo B. Sztein, Lauren Lawres
Rok vydání: 2021
Předmět:
Male
Proteomics
0301 basic medicine
Intravital Microscopy
Vesicle-Associated Membrane Protein 2
T-Lymphocytes
General Physics and Astronomy
R-SNARE Proteins
Mice
Ticks
Tandem Mass Spectrometry
Francisella tularensis
Pathogen
Skin
Mice
Knockout
Multidisciplinary
biology
Bacterial Infections
Ixodes scapularis
Infectious diseases
Pathogens
Anaplasma phagocytophilum
Science
030106 microbiology
Tick
Article
General Biochemistry
Genetics and Molecular Biology
Cell Line
Microbiology
Extracellular Vesicles
03 medical and health sciences
Microscopy
Electron
Transmission
parasitic diseases
Animals
Humans
Skin immunity
Dermacentor andersoni
Arthropods
Dermacentor
Inflammation
Ixodes
Bacteria
General Chemistry
bacterial infections and mycoses
biology.organism_classification
Mice
Inbred C57BL
Gene Ontology
030104 developmental biology
Vector (epidemiology)
Entomology
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
ISSN: 2041-1723
DOI: 10.1038/s41467-021-23900-8
Popis: Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.
Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.
Databáze: OpenAIRE
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