The impact of thyroid tumor features on lymph node metastasis in papillary thyroid carcinoma patients in head and neck department at KAMC: A retrospective cross-sectional study
| Autor: | Haddad Hussin Al-Kaf, Noor Z Farsi, Thamer A Alsufyani, Layan S Alhemayed, Reyan H Merdad, Mohammad A. Alessa, Anas I Alserif, Sherif K. Abdelmonim, Amjad O Aljohani, Ameen Z. Alherabi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Cross-sectional study medicine.medical_treatment Neck dissection 030230 surgery Malignancy Thyroid cancer Thyroid in Saudi Arabia Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Medicine Lymph node Original Research Lymph node metastasis business.industry Thyroid General Medicine medicine.disease medicine.anatomical_structure Cervical lymph nodes 030220 oncology & carcinogenesis Papillary thyroid carcinoma Surgery Radiology business |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Introduction Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid cancer. It is one of the most common types of malignancy of the thyroid that spreads to cervical lymph nodes. Lymph node metastasis (LNM) is an important factor when determining recurrence risk, and determining the extent of lymph node involvement can guide treatment. Our main objective is to evaluate the association between the size of the tumor and the number of lymph node metastases in patients with PTC. Methods: We conducted an electronic retrospective chart review of 125 patients with PTC followed in the Head and Neck Department at KAMC from 2009 to 2020. Twenty-two patients included in our study were pathologically and clinically diagnosed and confirmed to have LNM of PTC. Results: The study included 22 PTC patients who had undergone lymph node dissections. Patients had a median age of 38.8 years (IQR = 32.2–54.5), and the median tumor size was 20.5 mm. The most commonly affected level of the neck was IV (76.2%). Distant metastasis M1 was seen in only two patients (9.1%). Tumors sizes >30mm (75%) had ≥5 LNM. Most cases were the classic subtype PTC. For the site of the tumor, the site had a significant impact on the number of LNM (p = 0.004). Multifocality had a high impact on LNM (p = 0.019). Conclusions: This study showed no association between the size of PTC and the number of LNMs. The bilaterality of PTC was significantly associated with a high number of LNMs. Highlights • Lymph nodes in level IV were the most common metastasis site for PTC. • Bilateral and multifocal PTC were significantly associated with a higher number of lymph nodes metastasis. • The size of the tumor was not significantly related to the number of lymph node metastasis. |
| Databáze: | OpenAIRE |
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