Early experience with Millipede IRIS transcatheter mitral annuloplasty
| Autor: | Steven F. Bolling, Walter D. Boyd, Jason H. Rogers, Thomas W. Smith |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Mitral regurgitation
medicine.medical_specialty Ejection fraction business.industry Diastole Mitral ring 030204 cardiovascular system & hematology Nyha class 03 medical and health sciences 0302 clinical medicine Mitral annuloplasty ring Internal medicine Perspective cardiovascular system medicine Cardiology Surgery cardiovascular diseases 030212 general & internal medicine Ct imaging Cardiology and Cardiovascular Medicine business Mitral Annuloplasty |
| Zdroj: | Annals of Cardiothoracic Surgery. 7:780-786 |
| ISSN: | 2304-1021 2225-319X |
| DOI: | 10.21037/acs.2018.10.05 |
| Popis: | The IRIS mitral annuloplasty ring is a transcatheter, transfemoral and transseptal-delivered complete, semi-rigid annuloplasty ring. The IRIS system mimics surgical annuloplasty by reducing the mitral septal-lateral dimension and improving leaflet coaptation. We report the early experience with the IRIS system in seven patients. These patients had 3–4+ mitral regurgitation (MR) with annular dilation and were symptomatic NYHA II-IV with LV end systolic dimensions ≤65 mm. Patients were excluded for LVEF 70 mmHg. Baseline and 30-day transthoracic echocardiography and CT imaging was performed. In phase 1, 4 patients had surgical IRIS mitral ring implantation. In phase 2, 3 patients had transfemoral, transseptal delivery of the IRIS mitral ring. There was no procedural death, or MI. The mitral SL diameter was reduced from 38.0±4.1 to 25.9±4.9 mm at 30 days (31.8% SL reduction, n=7). MR was reduced from baseline 3–4+ to 0–1+ in all patients at 30 days. There were improvements in NYHA class and there was a decrease in diastolic LV volumes from 182.4±54.3 to 115.3±98.8 mL at 30 days (36.8% reduction). Based on these initial positive findings, ongoing clinical trials are underway to further evaluate the safety and efficacy of the IRIS ring. |
| Databáze: | OpenAIRE |
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