Comparative impact of systemic delivery of atorvastatin, simvastatin, and lovastatin on bone mineral density of the ovariectomized rats
| Autor: | Amir Kamali, Mostafa Shahrezaee, Sepanta Hosseinpour, Farshid Bastami, Ahmad Oryan, Mohammad Hossein Shahrezaee |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Simvastatin Endocrinology Diabetes and Metabolism Atorvastatin Ovariectomy Osteoporosis 030209 endocrinology & metabolism Bone remodeling Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Endocrinology Bone Density Internal medicine polycyclic compounds medicine Animals Femur Lovastatin Bone mineral business.industry Therapeutic effect nutritional and metabolic diseases X-Ray Microtomography medicine.disease Rats 030104 developmental biology Ovariectomized rat lipids (amino acids peptides and proteins) Female Hydroxymethylglutaryl-CoA Reductase Inhibitors business medicine.drug |
| Zdroj: | Endocrine. 60(1) |
| ISSN: | 1559-0100 |
| Popis: | In addition to lipid-lowering properties, statins have been suggested to affect bone turnover by increasing the osteoblastic bone formation and blocking the osteoclastogenesis. However, there are many controversial reports regarding the beneficial effect of statins on osteoporosis. In this study, we investigated the therapeutic effects of the most important lipophilic statins administered orally for 60 days to the ovariectomized (OVX) female Sprague–Dawley rats and compared the effects on different harvested trabecular and compact bones. Thirty female rats were divided into five equal groups including the normal rats, untreated OVX rats (negative control), and the OVX rats treated with atorvastatin (20 mg/kg/day), simvastatin (25 mg/kg/day), and lovastatin (20 mg/kg/day). The osteoporotic animals were treated daily for 60 days and euthanized at the end of experiments. The effectiveness of these treatments was evaluated by biomechanical testing, histopathologic, histomorphometric, micro-CT scan, real-time PCR, and serum biochemical analysis. Moreover, the hepatotoxicity and rhabdomyolysis related with these treatments were assessed by biochemistry analysis and histopathological evaluation. The results and statistical analysis showed that systemic delivery of simvastatin and lovastatin significantly increased serum calcium level, expression of osteogenic genes, bone mineral density (BMD), and biomechanical properties in comparison to the untreated OVX rats, especially in trabecular bones (P |
| Databáze: | OpenAIRE |
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