Pharmacokinetic interpretation of cephradine levels in serum after intravenous and extravascular administration in humans
| Autor: | Louis J. Ravin, Elisabeth S. Rattie, Peter D. Bernardo |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pharmacology
Adult Cephradine Male business.industry Administration Oral Biological Availability Absorption (skin) Injections Intramuscular Pharmacology and Therapeutics Dosage form Bioavailability Cephalosporins Kinetics Infectious Diseases Pharmacokinetics Injections Intravenous Medicine Humans Pharmacology (medical) Open model business Biological availability |
| Zdroj: | Antimicrobial agents and chemotherapy. 10(2) |
| ISSN: | 0066-4804 |
| Popis: | Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kinetics and that biological availability is complete from all dosage forms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|