Association between cardiovascular disease risk scores and subclinical atherosclerosis prevalence in non-elderly adult patients from Argentina

Autor: José L. Amigone, Darío G. Ferrer, Pablo A. Romagnoli, Gustavo A. Chiabrando, Raul H. Capra, Ricardo A. Albertini, María E. Tinti
Rok vydání: 2017
Předmět:
Carotid Artery Diseases
Male
Time Factors
Computed Tomography Angiography
Coronary Artery Disease
030204 cardiovascular system & hematology
SUBCLINICAL ATHEROSCLEROSIS
Coronary Angiography
Carotid Intima-Media Thickness
0302 clinical medicine
Risk Factors
Prevalence
Mass index
030212 general & internal medicine
ARGENTINA
Framingham Risk Score
Age Factors
Middle Aged
FRAMINGHAM RISK SCORES
Prognosis
Non elderly
Area Under Curve
Cohort
Female
Cardiology and Cardiovascular Medicine
CIENCIAS NATURALES Y EXACTAS
Adult
medicine.medical_specialty
animal structures
Otras Ciencias Biológicas
Argentina
CARDIOVASCULAR DISEASE
POOLED COHORT EQUATIONS
Risk Assessment
Decision Support Techniques
Ciencias Biológicas
03 medical and health sciences
Young Adult
Predictive Value of Tests
Internal medicine
Multidetector Computed Tomography
medicine
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Chi-Square Distribution
Adult patients
business.industry
Surgery
Cross-Sectional Studies
ROC Curve
Subclinical atherosclerosis
Asymptomatic Diseases
Disease risk
Observational study
business
Zdroj: The international journal of cardiovascular imaging. 33(10)
ISSN: 1875-8312
Popis: The goal of our study was to use statistical analysis to try to associate cardiovascular disease (CVD) risk scores and the observed prevalence of subclinical atherosclerosis (SA) in a non-elderly adult local population. An observational cross-sectional study was carried out (143 male and 131 female) on non-elderly adults (20?59 years). CVD risk scores included Framingham Risk Scores for 10-year hard (FRS 10 H), 30-year lipid hard or CVD (FRS 30 L H or FRS 30 L CVD), 30 year-body mass index hard or CVD (FRS 30 BMI H or FRS 30 BMI CVD) and Pooled Cohort Risk Equations for either 10 years (PCE 10) or lifetime (PCE LT). The Carotid Ultrasound (CU) study was performed and the Coronary Artery Calcium (CAC) score were obtained to assess SA. The Receiving Operating Characteristic (ROC) curve analysis followed by Youden?s index was used to evaluate and adjust the stratification of CVD risk scores. SA was detected in 32.4% of individuals. The risk scores that showed the biggest areas under the ROC curve were FRS 30 L (H and CVD). When the cut-off values for these CVD risk scores were adjusted, the FRS 30 L H increased the negative predictive value for the low risk group from 87.7 to 97.0% and the FRS 30 L CVD increased the positive predictive values for the high risk group from 69.7 to 85.7%. The CVD risk stratification of non-elderly adults using FRS 30 L H and FRS 30 L CVD may be a useful tool for selecting candidate patients for diagnostic imaging studies that assess their SA prevalence. Fil: Albertini, Ricardo A.. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Hospital Privado Centro Medico de Córdoba; Argentina Fil: Ferrer, Dario German. Hospital Privado Centro Medico de Córdoba; Argentina Fil: Romagnoli, Pablo A.. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina Fil: Tinti, María E.. Hospital Privado Centro Medico de Córdoba; Argentina Fil: Amigone, José L.. Hospital Privado Centro Medico de Córdoba; Argentina Fil: Capra, Raúl. Hospital Privado Centro Medico de Córdoba; Argentina Fil: Chiabrando, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Databáze: OpenAIRE
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