Inhalation toxicity of methyl isocyanate: biochemical and cytological profile of bronchoalveolar lavage fluid in rats
| Autor: | Syed H. N. Naqvi, Renu Dixit, J.L. Kaw, Govind Sharan Gupta, P. K. Ray |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pulmonary toxicity Pharmacology Methyl isocyanate Toxicology chemistry.chemical_compound Antisickling Agents Administration Inhalation Medicine Animals Lactic Acid Lung Cyanates Inhalation exposure Inhalation medicine.diagnostic_test business.industry Body Weight Proteins Rats Inbred Strains respiratory system N-Acetylneuraminic Acid Lactic acid Rats Trachea Bronchoalveolar lavage medicine.anatomical_structure chemistry Toxicity Lactates Sialic Acids business Bronchoalveolar Lavage Fluid Isocyanates |
| Zdroj: | Journal of applied toxicology : JAT. 11(3) |
| ISSN: | 0260-437X |
| Popis: | Acute pulmonary injury in rats following a single inhalation exposure to methyl isocyanate (3.2 mg I−1) was reflected by alterations in the biochemical and cytological constituents of bronchoalveolar lavage fluid (BALF) over a period of 30 days. Total protein, sialic acid and lactic acid contents of BALF were increased followed by a gradual decline to normalcy between day 3 and day 30 post-exposure. The activity of lactic dehydrogenase also increased progressively with time. The cellularity of BALF was increased significantly and primarily comprised of polymorphonuclear neutrophils at 8 days. The adherence of macrophages was unchanged but their viability was lowered at 30 days post-exposure. The results indicate the significance of bronchoalveolar lavage analysis in monitoring pulmonary toxicity by methyl isocyanate, which is characterized by the hypoxic condition and reduced cellular defence. Some toxic manifestations are potentially reversible with time after cessation of exposure. |
| Databáze: | OpenAIRE |
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