Endothelial Dysfunction and Cardiac Allograft Vasculopathy
| Autor: | Monica Colvin-Adams, Nonyelum Harcourt, Daniel Duprez |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Screening techniques
medicine.medical_specialty Endothelium medicine.medical_treatment Treatment outcome Pharmaceutical Science Coronary Artery Disease Disease Cardiac allograft vasculopathy Internal medicine Genetics Animals Humans Medicine Endothelial dysfunction Genetics (clinical) Heart transplantation business.industry Graft Survival Vascular System Injuries medicine.disease Coronary Vessels Treatment Outcome surgical procedures operative medicine.anatomical_structure Cardiology Heart Transplantation Molecular Medicine Graft survival Endothelium Vascular Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Translational Research. 6:263-277 |
| ISSN: | 1937-5395 1937-5387 |
| DOI: | 10.1007/s12265-012-9414-3 |
| Popis: | Cardiac allograft vasculopathy remains a major challenge to long-term survival after heart transplantation. Endothelial injury and dysfunction, as a result of multifactorial immunologic and nonimmunologic insults in the donor and the recipient, are prevalent early after transplant and may be precursors to overt cardiac allograft vasculopathy. Current strategies for managing cardiac allograft vasculopathy, however, rely on the identification and treatment of established disease. Improved understanding of mechanisms leading to endothelial dysfunction in heart transplant recipients may provide the foundation for the development of sensitive screening techniques and preventive therapies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink