Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)
| Autor: | H Le Buenac, J Rappaport, Jean-François Zagury, D. Zagury, Bernard Bizzini, G Jaureguiberry, A Lachgar |
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| Rok vydání: | 1998 |
| Předmět: |
Chemokine
Erythrocytes Protozoan Proteins Antigens Protozoan Enzyme-Linked Immunosorbent Assay Receptors Cell Surface In Vitro Techniques Biology Chemokine receptor Antigen medicine Humans Interleukin 8 Receptor Macrophage inflammatory protein Pharmacology General Medicine biology.organism_classification Molecular biology Receptors Antigen Red blood cell medicine.anatomical_structure Plasmodium knowlesi Immunology HIV-1 biology.protein Chemokines Carrier Proteins Duffy Blood-Group System |
| Zdroj: | Biomedicine & Pharmacotherapy. 52:436-439 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/s0753-3322(99)80021-3 |
| Popis: | The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES), but not macrophage inflammatory protein 1 alpha (MIP-1 alpha) or MIP-1 beta. DARC has also been identified to a receptor for malaria parasites Plasmodium vivax and Plasmodium knowlesi. In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to peripheral blood mononuclear cells (PBMCs). Furthermore, binding of HIV-1 particles to RBCs is inhibited by treating these cells with recombinant RANTES, but not with recombinant MIP-1 alpha prior to their incubation with HIV-1. This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells. |
| Databáze: | OpenAIRE |
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