Somatostatin-Like Immunoreactivity in the Cerebrospinal Fluid of Aged Patients with Parkinson's Disease
| Autor: | F. Kuntzmann, I. Popescu, Hinrich Cramer, D. Strubel, H. Masson |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Somatostatin-like immunoreactivity Severity of Illness Index Levodopa Benserazide Cerebrospinal fluid Statistical significance Internal medicine medicine Humans In patient Bromocriptine Aged Aged 80 and over business.industry Homovanillic Acid Parkinson Disease Hydroxyindoleacetic Acid medicine.disease Control subjects Aged patients Endocrinology Somatostatin Female Geriatrics and Gerontology Cognition Disorders business |
| Zdroj: | Journal of the American Geriatrics Society. 38:19-24 |
| ISSN: | 0002-8614 |
| DOI: | 10.1111/j.1532-5415.1990.tb01591.x |
| Popis: | Cerebrospinal fluid (CSF) somatostatin concentrations were measured in 35 aged patients with Parkinson's disease (mean age, 79.5 years) and 11 control subjects (mean age, 82.3 years). In patients with Parkinson's disease the levels of somatostatin-like immunoreactivity were lower than in controls (P less than .02); these values were lowest in the untreated group. Somatostatin-like immunoreactivity levels in the CSF tended to increase with treatment but not significantly (P = .11). Somatostatin values were not correlated to age, sex, or duration of the disease. Somatostatin concentrations tended to be lower in more severely affected patients with higher scores on the Hoehn and Yahr (P = .13) and Webster staging scales (P = .13) and lower scores on Mini-Mental State (P = .10), but without statistical significance for these correlations. |
| Databáze: | OpenAIRE |
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