Diagnostic accuracy of nodular gastritis for H. pylori infection
| Autor: | Erika Marroquín-Fabian, Eva Juárez-Hernández, Misael Uribe, Juan L. Romero-Flores, Norberto C. Chávez-Tapia, Félix I. Téllez-Ávila, Justo A Fernandez-Rivero, Beatriz Sanchez-Jimenez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Therapeutics and Clinical Risk Management specificity Diagnostic accuracy Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy medicine Pharmacology (medical) Sampling (medicine) General Pharmacology Toxicology and Pharmaceutics endoscopy Original Research Chemical Health and Safety Nodular gastritis medicine.diagnostic_test biology business.industry histopathologic General Medicine Helicobacter pylori H pylori infection biology.organism_classification sensitivity Endoscopy 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Radiology business Safety Research Kappa |
| Zdroj: | Therapeutics and Clinical Risk Management |
| ISSN: | 1178-203X 1176-6336 |
| Popis: | Juan L Romero-Flores,1 Justo A Fernandez-Rivero,1 Erika Marroquín-Fabian,1 Félix I Téllez-Ávila,2 Beatriz A Sánchez-Jiménez,1 Eva Juárez-Hernández,3 Misael Uribe,1 Norberto C Chávez-Tapia1,3 1Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, 2Department of Gastrointestinal Endoscopy, Instituto Nacional de Ciencias Médicas y Nutrición SalvadorZubirán, 3Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico Background: The term nodular is not included in the Sydney classification and there is no widely accepted histopathological definition. It has been proposed that the presence of antral nodularity could predict Helicobacter pylori (H. pylori) infection. The aim of this study was to determine the diagnostic accuracy of nodular gastritis (NG) for H. pylori infection after a rigorous standardization process, and to describe the associated histopathological characteristics. Materials and methods: Endoscopic images of patients submitted to endoscopy with biopsy sampling were included. Endoscopic images were distributed among six endoscopists. The analysis was performed sequentially in three rounds: the first round assessed the interobserver variability, the second evaluated the intraobserver variability, and the third calculated the interobserver variability after training. A correlation analysis between endoscopic and histopathological findings was performed. Results: A total of 917 studies were included. In the first analysis of interobserver variability, a poor kappa value (0.078) was obtained. The second evaluation yielded good intraobserver variability, with kappa values of 0.62–0.86. The evaluation of interobserver variability after training revealed an improvement in the kappa value of 0.42. A correlation was found between endoscopic images and histopathological reports. Conclusion: There was a strong correlation between NG and H. pylori, but only after rigorous evaluation. The use of the term NG requires extensive standardization before it can be used clinically. Keywords: sensitivity, specificity, endoscopy, histopathologic |
| Databáze: | OpenAIRE |
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