Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength
| Autor: | Paul J. Fuss, Susan B. Racette, James Rochon, Mary L. Uhrich, Corby K. Martin, Manjushri Bhapkar, Susan B. Roberts, Luigi Fontana, Leanne M. Redman, Dennis T. Villareal, William E. Kraus, Sai Krupa Das |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty CALERIE CARDIORESPIRATORY FITNESS CR ENDURANCE VO2max Orthopedics and Sports Medicine Physical Therapy Sports Therapy and Rehabilitation Physical Therapy Calorie restriction Physiology Sports Therapy and Rehabilitation law.invention Body Mass Index 03 medical and health sciences Young Adult Oxygen Consumption Randomized controlled trial law Weight loss Weight Loss Medicine Humans Longitudinal Studies Muscle Strength Aerobic capacity Caloric Restriction business.industry Applied Sciences Cardiorespiratory fitness Middle Aged Overweight V˙O2max 030104 developmental biology Muscle strength Physical therapy Exercise Test Physical Endurance Female Dietary Proteins medicine.symptom business Body mass index |
| Zdroj: | Medicine and Science in Sports and Exercise |
| Popis: | Purpose Calorie restriction (CR) improves health span and delays age-related diseases in many species. The multicenter Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was the first randomized controlled trial of CR in nonobese humans. The aim of this investigation was to determine the effects of CR on V˙O2max and muscle strength in the CALERIE trial. Methods Healthy, normal-weight, and mildly overweight women and men (n = 218, mean ± SE age = 37.9 ± 0.5 yr) were randomized to 25% CR or an ad libitum (AL) control condition in a 2:1 allocation (143 CR, 75 AL). V˙O2max was determined with an incremental treadmill test; the strength of the knee flexors and extensors was assessed by dynamometry at baseline, 1 yr, and 2 yr. Results The CR group achieved an average 11.9% ± 0.7% CR during the 2-yr intervention. Body weight decreased in CR (−7.7 ± 0.4 kg), but not AL (+0.2 ± 0.5 kg). Absolute V˙O2max (L·min−1) decreased at 1 and 2 yr with CR, whereas V˙O2max expressed relative to body mass increased at both time points (1 yr: +2.2 ± 0.4; 2 yr: +1.9 ± 0.5 mL·kg−1·min−1) and relative to AL. The CR group increased their treadmill test time and workload at 1 and 2 yr. Strength results in CR were similar, with decreases in absolute flexor and extensor strength, but increases when expressed relative to body mass. No changes were observed for V˙O2max expressed relative to lean body mass or leg lean mass. Conclusions Two years of modest CR without a structured exercise component did not appear to compromise aerobic capacity in healthy nonobese adults. The clinical implications of the observed changes in V˙O2max and muscle strength will be important to explore in future studies. |
| Databáze: | OpenAIRE |
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