Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy
| Autor: | José G. Merino, Antonio Arauz, Juan Calleja, Juan Camilo Vargas-Gonzalez, Nayelli Arguelles-Morales, Angélica Ruiz-Franco, Miguel A Barboza, Alejandro Quiroz-Compean, Elizabeth Martínez-Jurado |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Neuroimaging 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine In patient Mr venography Stroke Survival analysis Retrospective Studies Venous Thrombosis business.industry Proportional hazards model Age Factors Anticoagulants Brain Mean age Phlebography Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Psychiatry and Mental health Venous thrombosis Female Neurology (clinical) Radiology Intracranial Thrombosis business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 87:247-251 |
| ISSN: | 1468-330X 0022-3050 |
| Popis: | Few studies have investigated the rates of recanalisation after cerebral venous thrombosis (CVT). Our objective was to investigate the recanalisation rate and to identify predictors of recanalisation in patients with CVT.We included 102 patients with confirmed first-ever, non-septic CVT. All patients received anticoagulation for 12 months or until complete recanalisation. To assess recanalisation, patients underwent MR venography every 3 months until partial or complete recanalisation or for 12 months after diagnosis. We conducted two parallel analyses of complete recanalisation versus partial and no recanalisation versus any recanalisation. As a secondary objective we explored the influence of recanalisation on outcome and recurrent events. We calculated the probability of recanalisation using Kaplan-Meier analysis and conducted multivariate analysis using a Cox model.The mean age of patients was 33.5±11 years (80 (78.4%) women). Survival analysis indicated that 50% of the patients had any recanalisation (grades I, II and III) by 64 days and complete recanalisation (grade III) by 169 days. Adjusted Cox proportional model revealed that age50 years (HR=11.5 95% CI=1.58 to 84.46, p=0.01) and isolated superior sagittal sinus thrombosis (HR=0.39, 95% CI=0.14 to 1.04, p=0.05) predict complete recanalisation, while age50 years (HR=4.79; 95% CI=1.69 to 13.5, p=0.003) predicts any recanalisation. Patients with complete recanalisation had a greater chance of good functional outcome (HR=5.17; 95% CI=2.8 to 9.53, p0.001).We found that recanalisation occurs over time, until month 11. Complete recanalisation may influence functional outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|